We have examined the redox equilibria of azidomethemoglobin (low-spin) and fluoromethemoglobin (high-spin). We have derived a modified Hill equation which includes the tetramer--dimer equilibrium of the oxidized form, and also generalized the two-state model to incorporate ligand binding to the ferriheme. The pH dependence of the redox Hill's constant for fluoromethemoglobin is the same as that...

In the title compound, C(26)H(22)F(2)O(2), the cyclo-propane ring makes dihedral angles of 47.6 (2), 51.3 (2) and 63.9 (2)° with the 2-fluoro-substituted phenyl ring, the unsubstituted phenyl ring and the 4-fluoro-substituted phenyl ring, respectively. There is a short C-H⋯F contact in the molecule. In the crystal, weak C-H⋯F hydrogen bonds lead to chains of mol-ecules extending along the b-axi...

In the title compound, C12H15FN2O2S, the mol-ecule adopts a cis configuration of the fluoro-benzoyl group with respect to the thiono group about their C-N bond. The dihedral angle between the fluoro-benzoyl group and the thio-urea N2CS fragment is 69.60 (11)°. An intra-molecular N-H⋯O hydrogen bond occurs. In the crystal, mol-ecules form chains along the b-axis direction via O-H⋯S and C-H⋯O hyd...

Unnatural uridine diphosphate (UDP)-sugar donors, UDP-4-deoxy-4-fluoro-N-acetylglucosamine (4FGlcNAc) and UDP-4-deoxy-4-fluoro-N-acetylgalactosamine (4FGalNAc), were prepared using both chemical and chemoenzymatic syntheses relying on N-acetylglucosamine-1-phosphate uridylyltransferase (GlmU). The resulting unnatural UDP-sugar donors were then tested as substrates in glycosaminoglycan synthesis...

In the title compound, [Pd(CF3)(C6H4F)(C6H16N2)], the Pd(II) cation is four-coordinated by the two N atoms of the N,N,N',N'-tetra-methyl-ethylenedi-amine ligand and by one C atom each from a 4-fluoro-phenyl and a tri-fluoro-methyl ligand, in a distorted rectangular-planar geometry, with an average deviation from the least-squares plane of 0.066 (2) Å. The central coordination angles with the Pd...

In the title complex, [Ir(C(16)H(9)F(2)N(2))(2)(C(5)H(7)O(2))], the Ir(III) atom, lying on a twofold rotation axis, is hexa-coordinated in a distorted octa-hedral geometry by two C,N-bidentate 5-fluoro-2-[3-(4-fluoro-phen-yl)pyrazin-2-yl]phenyl ligands and one O,O'-bidentate acetyl-acetonate ligand. The dihedral angles between the benzene rings and the pyrazine ring are 14.66 (8) and 49.76 (12)°.

BACKGROUND An excess of mortality for malignant neoplasms of the pleura in Biancavilla, promoted an investigation for pleural mesothelioma, disclosing 17 cases. As the absence of known sources of asbestos exposure, a local stone quarry, located near the inhabited area, used for the extraction of building materials, was investigated. Amphibolic fibres were found in the quarry and identified as f...

Reported herein is a light-triggered organocatalytic strategy for the desymmetrization of achiral 2-fluoro-substituted cyclopentane-1,3-diketones. The chemistry is based on an intermolecular aldol reaction of photochemically generated hydroxy-o-quinodimethanes and simultaneously forges two adjacent fully substituted carbon stereocenters, with one bearing a stereogenic carbon-fluorine unit. The ...

In the title compound, [Cu(C(8)F(4)O(4))(C(5)H(5)N)(3)](n), the Cu(II) atom, lying on a twofold rotation axis, is five-coordinated by two O atoms from two tetra-fluoro-terephthalate ligands and three N atoms from three pyridine ligands in a distorted trigonal-bipyramidal geometry. Adjacent Cu(II) atoms are connected via the bridging tetra-fluoro-terephthalate ligands into a one-dimensional chai...

In the crystal structure of the title compound, C(15)H(10)FNO, the furan ring makes dihedral angles of 40.04 (11) and 25.71 (11)° with the pyridine and 4-fluoro-phenyl rings, respectively. The pyridine ring makes a dihedral angle of 49.51 (10)° with the 4-fluoro-phenyl ring. Non-conventional C-H⋯F and C-H⋯N hydrogen bonds are effective in the stabilization of the crystal structure.