The unexpected discoveries at the beginning of the century, particularly thanks to Heisenberg, Bohr, and Gödel, has driven the science to drastic changes, opening new, extraordinary, and infinite research fields. After this, many scientists saw, and still today see, a crisis, with dreadful meaning, in the science. However, this crisis is only present in that type of science, driven by determini...

PUVA therapy is widely used for early stage mycosis fungoides. While the efficacy of PUVA with oral 8-methoxypsoralen (8-MOP) is well documented, the use of its topical variation, bath-water PUVA therapy with 8-MOP has not been studied. The purpose of this study was to assess the effect of 8-MOP bath-water PUVA therapy in adult patients with early stage mycosis fungoides. We retrospectively eva...

abstract background: research studies on reproductive mechanism of laboratory animals are essential for further advancement of assisted reproductive techniques (art). one of these studies includes the assessment of in-vitro development of pre-implantation embryos. the objective was to compare the cleavage rates and morphology of in-vivo formed 2 to 8 cell embryos and blastocysts with in-vitro c...

Myeloperoxidase (MPO) generates reactive halogenating species that can modify DNA. The aim of this study was to investigate the formation of 8-halogenated 2'-deoxyguanosines (8- halo-dGs) during inflammatory events. 8-Bromo-2'-dG (8-BrdG) and 8-chloro-2'-dG (8-CldG) were generated by treatment of MPO with hydrogen peroxide at physiological concentrations of Cl(-) and Br(-). The formation of 8-h...

BACKGROUND Asymmetric cell divisions are involved in the divergence of the first two lineages of the pre-implantation mouse embryo. They first take place after cell polarization (during compaction) at the 8-cell stage. It is thought that, in contrast to many species, spindle orientation is random, although there is no direct evidence for this. METHODOLOGY/PRINCIPAL FINDINGS Tubulin-GFP and li...

OBJECTIVES This study examined the reproducibility of speed corresponding to specific lactate markers during incremental treadmill running of normal and prolonged stage durations. DESIGN Nineteen healthy participants (14 male, 5 female) performed repeated, incremental treadmill running trials of 4 and 8 min stages on separate days to examine the test-retest reproducibility of speed at lactate...