Abstract : Foot and Mouth Disease is one of  the important live stocks contagious viral disease caused by Aphtovirus genus ,  that is belong to family RNA virus  picornaviride. The important characteristic of FMD virus is high mutation that give rise to diversity of Antigen in surface of Neutralizing proteins. For this reason FMD virus have 7 distinct serotype and many subtype. Vaccination is o...

Foot-and-mouth is a disease of global socioeconomic importance, with vaccination the principle tool for control in endemic countries. Improvements in vaccines require advances in our understanding of the host immune response, one aspect of which the study group is asked to consider. Major problems limit the capacity of FMDV vaccines to control infections in developing countries. The virus is no...

Foot and mouth disease (FMD) is a highly infectious and economically devastating disease of livestock. Although vaccines, available since the early 1900s, have been instrumental in eradicating FMD from parts of the world, the disease still affects millions of animals around the globe and remains the main sanitary barrier to the commerce of animals and animal products. Currently available inacti...

In the first 1 of this series of papers we described the strain of footand-mouth disease virus employed in our studies. We have also reported therein that guinea pigs were susceptible to the active agent in dilutions of 1: 10,000,000, and that the virus was non-centrifugable. The indications pointed to a minute size of the incitant. In the experiments to be presented in this article on cataphor...

Binding of foot-and-mouth disease virus (FMDV) to cells requires an arginine-glycine-aspartic acid (RGD) sequence in the capsid protein VP1. We have genetically engineered an FMDV in which these three amino acids have been deleted, producing a virus particle which is unable to bind to cells. Cattle vaccinated with these receptor binding site-deleted virions were protected from disease when chal...

-The foot-and-mouth disease virus-RNA polymerase complex was released from membrane particulates present in the cytoplasm of infected baby hamster kidney cells. The soluble polymerase complex was fractionated by zonal centrifugation in sucrose gradients. Two polymerase complexes (RNA and protein complex) active in the cell-free system were isolated and had S-rate ranges of 20-70S and 100-300S, ...

Foot-and-Mouth Disease Virus (FMDV) is a member of the Picornaviridae family of viruses, which includes viruses that cause a number of high consequence human and animal diseases in addition to Foot-and-Mouth Disease (FMD), such as hand-foot-and-mouth disease, herpangina, polio, and encephalomyocarditis. FMDV infects domestic and wild cloven-hoofed animals, including bovine, caprine, ovine and s...