A reduced model technique based on a reduced number of numerical simulations at a subset of operating conditions for a perfectly stirred reactor is developed in order to increase the rate of convergence of a genetic algorithm (GA) used for determining new reaction rate parameters of chemical kinetics mechanisms. The genetic algorithm employed uses perfectly stirred reactor, laminar premixed fla...

Almost half of all cases of severe hemophilia A are caused by recurrent DNA inversions, which disrupt the factor VIII (FVIII) gene. These inversions generally occur between a region of intron 22 (int22h) and one of two homologous copies of this region, located 300 to 400 kb telomeric to the FVIII gene. They are routinely detected by a Bcl I Southern blot assay in which the sizes of two of the t...

seismic inversion is a method that extracts acoustic impedance data from the seismic traces. sourcewavelets are band-limited, and thus seismic traces do not contain low and high frequency information.therefore, there is a serious problem when the deterministic seismic inversion is applied to real dataand the result of deterministic inversion is smooth. low frequency component is obtained from w...

The most frequent mutations resulting in hemophilia A are an intron 22 or intron 1 gene inversion, which together cause ∼50% of severe hemophilia A cases. We report a simple and accurate RNA-based assay to detect these mutations in patients and heterozygous carriers. The assays do not require specialized equipment or expensive reagents; therefore, they may provide useful and economic protocols ...

Oculo-auriculovertebral dysplasia (Goldenhar) is a congenital syndrome. Its phenotype differs from craniofacial anomalies to cardiac, vertebral or central nervous system defects. This syndrome is rare and its etiology is not apparent yet. Pericentric inversion of chromosome 9 is one of the most common structural balanced chromosomal aberrations with its incidences 15% to 25%. Herein we present ...

here in, an application of a new seismic inversion algorithm in one of iran’s oilfields is described. stochastic (geostatistical) seismic inversion, as a complementary method to deterministic inversion, is perceived as contribution combination of geostatistics and seismic inversion algorithm. this method integrates information from different data sources with different scales, as prior informat...

The uncatalyzed, thermal N-inversion reactions were studied of pyrimidin-4(3H)-imine (PMI), pyridin-2(1H)-imine (PYI), and 1H-purine-6(9H)-imine (PUI). Relevant regions of the potential energy surfaces were explored with second-order Moller-Plesset perturbation theory (MP2(full)/6-31G(d)) and with coupled cluster theory (CCSD/6-31G(d), CCSD/6-31+G(d)). The thermochemistry of stationary structur...