Current research has been done to develop statistically and optimized immediate release tablets for eslicarbazepine. Nineteen formulations of eslicarbazepine acetate are prepared by wet granulation. The three-dimensional Box-Behnken design at three levels (33) was developed study how selected independent variables affect dependent responses. After the initial test, items were as follows; polyvi...

solid lipid nanoparticles of atovaquone (atq-sln) were prepared by high shearhomogenization method using tripalmitin, trilaurin, and compritol 888 ato as the lipidmatrices and phospholipon 90h, tween 80, and poloxamer 188 as the surfactants. optimizationof the formulations was conducted using 6 sets of 24 full-factorial design based on fourindependent variables that were the number of homogeniz...

The formulation of the process of analog system design has been done on the basis of the control theory application as the problem of a special functional minimization. This approach generalizes the design process and produces the different design trajectories inside the same optimization procedure. Numerical examples show that the potential computer time gain of the optimal design strategy wit...

The fixed-charge capacitated multicommodity network design formulation (CMND) represents a generic model for a wide range of applications in planning the construction, development, improvement, and operation of transportation, logistics, telecommunication, and production systems (Balakrishnan, Magnanti, and Mirchandani 1997 and references therein). In these applications, multiple commodities (g...