Image restoration is an essential preprocessing step for many image analysis applications. In any image restoration techniques, keeping structure of the image unchanged is very important. Such structure in an image often corresponds to the region discontinuities and edges. The techniques based on partial differential equations, such as the heat equations, are receiving considerable attention i...

The objective of this study was to determine whether the voltage-sensitive release mechanism (VSRM) can be stimulated independently from Ca(2+)-induced Ca(2+) release (CICR) by drugs that elevate intracellular cAMP. Contractions were measured in voltage-clamped guinea pig ventricular myocytes at 37 degrees C. Na(+) current was blocked. We compared effects of agents that elevate cAMP through act...

Insulin stimulation of adipocytes results in serine phosphorylation/activation of phosphodiesterase 3B (PDE 3B) and activation of a kinase that phosphorylates PDE 3B in vitro, key events in the antilipolytic action of this hormone. We have investigated the role for p70 S6 kinase, mitogen-activated protein kinases (MAP kinases), and protein kinase B (PKB) in the insulin signaling pathway leading...

Cyclic nucleotides have been implicated in the differentiation and function of the vertebrate retina . In the normal retina of DBA mice, the specific activity of cyclic-nucleotide phosphodiesterase (PDE), with cyclic-AMP as the substrate (cAMP-PDE), increases eightfold between the 6th and 20th postnatal day. Kinetic analysis of retinae from newborn mice reveals a PDE with a single Michaelis con...

A thermal–electrochemical model of lithium-ion batteries is presented and a Luenberger observer is derived for State-of-Charge (SoC) estimation by recovering the lithium concentration in the electrodes. This first-principles based model is a coupled system of partial and ordinary differential equations, which is a reduced version of the Doyle–Fuller–Newman model. More precisely, the subsystem o...

Pulse detonation technology can be a revolutionary approach for propulsion system since it offers significant fuel efficiency, higher thrust to weight ratio and low cost. Although the design concept of a pulse detonation engine is comparatively simple, but the development and stabilization of sustainable detonation wave front is difficult. Consequently pulse detonation engine technology is stil...

The main issue in any image zooming techniques is to preserve the structure of the zoomed image. The zoomed image may suffer from the discontinuities in the soft regions and edges; it may contain artifacts, such as image blurring and blocky, and staircase effects. This paper presents a novel image zooming technique using Partial Differential Equations (PDEs). It combines a non-linear Fourth-ord...

A central step in vertebrate visual transduction is the rapid drop in cGMP levels that causes cGMP-gated ion channels in the photoreceptor cell membrane to close. It has long been a puzzle that the cGMP phosphodiesterase (PDE) whose activation causes this decrease contains not only catalytic sites for cGMP hydrolysis but also noncatalytic cGMP binding sites. Recent work has shown that occupancy...