نتایج جستجو برای: frailty models
تعداد نتایج: 915874 فیلتر نتایج به سال:
The inclusion of latent frailties in survival models can serve two purposes: (1) the modelling of dependence in clustered data, (2) explaining lack of fit of univariate survival models, like deviation from the proportional hazards assumption. Multi-state models are somewhere between univariate data and clustered data. Frailty models can help in understanding the dependence in sequential transit...
Multivariate survival data arise when each study subject may experience multiple events or when study subjects are clustered into groups. Statistical analyses of such data need to account for the intra-cluster dependence through appropriate modeling. Frailty models are the most popular for such failure time data. However, there are other approaches which model the dependence structure directly....
In the analysis of survival data with parametric models, it is well known that the Weibull model is not suitable for modeling survival data where the hazard rate is non-monotonic. For such cases, where hazard rates are bathtub-shaped or unimodal (or hump-shaped), log-logistic, lognormal, Birnbaun-Saunders, and inverse Gaussian models are used for the computational simplicity and popularity amon...
Purpose Anthropometry is a useful tool for assessing some risk factors for frailty. Thus, the aim of this study was to verify the discriminatory performance of anthropometric measures in identifying frailty in the elderly and to create an easy-to-use tool. Methods Cross-sectional study: a subset from the Multidimensional Study of the Elderly in the Family Health Strategy (EMI-SUS) evaluating ...
BACKGROUND AND OBJECTIVES Patients of all ages undergoing hemodialysis (HD) have a high prevalence of cognitive impairment and worse cognitive function than healthy controls, and those with dementia are at high risk of death. Frailty has been associated with poor cognitive function in older adults without kidney disease. We hypothesized that frailty might also be associated with poor cognitive ...
PURPOSE Exploring the domains and degrees of health-related quality of life (HRQOL) that are affected by the frailty of elders will help clinicians understand the impact of frailty. This association has not been investigated in community-dwelling elders. Therefore, we examined the domains and degree of HRQOL of elders with frailty in the community in Taiwan. METHODS A total of 933 subjects ag...
BACKGROUND Higher levels of frailty result in higher risks of adverse frailty outcomes such as hospitalisation and mortality. There are, however, indications that more factors than solely frailty play a role in the development of these outcomes. The presence of resources, e.g. sufficient income and good self-management abilities, might slow down the pathway from level of frailty to adverse outc...
BACKGROUND The number of older cancer patients is rising. Especially in older people, treatment considerations should balance the impact of disease and treatment on quality of life (QOL) and survival. How a cancer diagnosis in older people interacts with concomitant frailty to impact on QOL is largely unknown. We aimed to determine the association between frailty and QOL among community-dwellin...
BACKGROUND Despite knowing better how to screen older adults, understanding how frailty progression might be modified is unclear. We explored effects of modifiable and non-modifiable factors on changes in frailty in community-dwelling adults aged 50+ years who participated in the Canadian Multicentre Osteoporosis Study (CaMos). METHODS Rates of change in frailty over 10 years were examined us...
Background: Chronic low-grade inflammation may be a cardinal pathophysiologic feature in the pathogenesis of frailty. Interferon-gamma (INF-γ) is an understudied proinflammatory cytokine in frailty that induces many inflammatory pathways including the guanosine triphosphate cyclohydrolase 1 (GTP-CH1) pathway. Our aim was to evaluate the GTP-CH1 pathway in Egyptian frail elderly subjects. ...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید