We use a drift-diffusion model to study frequency dependent harmonic powers in a modified uni-traveling carrier (MUTC) phododetector. The model includes external loading, incomplete ionization, the Franz-Keldysh effect, and history-dependent impact ionization. In three-tone measurements, the bias voltage at which a null occurs (bias null) in the second-order intermodulation distortion (IMD2) is...

Flavonoids are bioactive phytochemicals that exhibit protective potential against cutaneous inflammation and photoaging. We selected eight flavonoid aglycones or glycosides to elucidate the chemistry behind their skin absorption capability through experimental and computational approaches. The skin delivery was conducted using nude mouse and pig skins mounted on an in vitro Franz cell assembly....

Liposomes have been intensively investigated as carriers for different applications in dermatology and cosmetics. Ascorbic acid has potent antioxidant and anti-inflammatory properties preventing photodamage of keratinocytes; however, due to its instability and low skin penetration, an appropriate carrier is mandatory to obtain desirable efficacy. The present work investigates the ability of a s...

In the present study, two methods were used to evaluate the in vitro release of leuprolide acetate (LA) from poly(lactide-co-glycolide) (PLGA) microspheres: Franz diffusion cells, typically referred to as “vertical diffusion cells” (VDC), and rotating bottle apparatus (RBA), both modified with a dialysis membrane. This hydrosoluble peptide was chosen as a model drug to study different possibili...

Obesity is associated with insulin resistance and other major cardiovascular risk factors. A common amino acid polymorphism at codon 972 of the insulin receptor substrate-1 (IRS-1) has been shown to interact with obesity in the expression of insulin resistance. The plasma concentration of the adipocyte-specific hormone leptin is increased in obesity and is correlated with adipose tissue mass. B...

Abstract: Background/Aim: Inflammation typically occurs when infectious microorganisms enter the body, settle in specific tissues, and/or circulate blood. Asparagus racemosus extract contains various saponins and flavonoids plant-origin drugs have fewer side effects toxicity. The phytoconstituents less permeability through skin; to enhance their effectiveness it was loaded niosomes. Therefore, ...

classi¢cation scheme Charles M. A. P. Franz, Marco J. van Belkum, Wilhelm H. Holzapfel, Hikmate Abriouel & Antonio Gálvez Federal Research Centre for Nutrition and Food, Institute for Hygiene and Toxicology, Karlsruhe, Germany; Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada; and Departamento de Ciencias de la Salud, Área de Microbiologı́a, Facultad de Ciencias Experime...