Abstract Large-area and transparent all-dielectric metasurfaces sustaining photonic bound states in the continuum (BICs) provide a set of fundamental advantages for ultrasensitive biosensing. BICs bridge gap large effective mode volume with experimental quality factor. Relying on transduction mechanism reactive sensing principle, herein, we first numerically study potential subwavelength confin...

Noninvasive diagnosis of Alzheimer’s disease (AD) is important for patients. Significant differences in the methylation mitochondrial DNA (mtDNA) were found AD brain tissue. Cell-free (cfDNA) a noninvasive and economical diagnostic tool. We aimed to characterize mtDNA alterations plasma cfDNA 31 patients 26 age- sex-matched cognitively normal control subjects. that patterns differed between The...