Past research has demonstrated that performance on frontal lobe-dependent tasks is associated with dopamine system integrity and that various dopamine system deficits occur with aging. The positron emission tomography (PET) radiotracer 6-[(18)F]fluoro-l-m-tyrosine (FMT) is a substrate of the dopamine-synthesizing enzyme, aromatic amino acid decarboxylase (AADC). Studies using 6-[(18)F]fluorodop...

Background: The aim of the present study was to examine whether thought control strategies can determine emotion regulation abilities in patients with frontal lobe epilepsy. Methods: 35 Patients with frontal lobe epilepsy and 35 healthy individuals completed emotion regulation questionnaire (Gross & John, 2003) and rated their thoughts on thought control questionnaire (Wells & Davies, 1994). Re...

Background and Objectives: Gliomas are the most prevalent subgroup of primary brain tumors with a relatively high mortality. However, oligodendrogliomas have a better prognosis compared to other subtypes due to their sensitivity to chemotherapy. Considering the low incidence and the resulting lack of information about oligodendrogliomas, particularly i...

specialized systems—each handling specific kinds of information, working relatively independently of each other to do routine tasks. When presented with a new task, however, these systems need to develop a responsive program. this process of defining the task, and designing a program to respond, is part of the brain’s executive functions, which are believed to be mostly located in the anterior ...

Is there a single executive process or are there multiple executive processes that work together towards the same goal in some task? In these experiments, we use counter switching and response inhibition tasks to examine the neural underpinnings of two cognitive processes that have often been identified as potential executive processes: the switching of attention between tasks, and the resoluti...

Whether frontal lobe pathology can account for some of the cognitive impairment observed in amnesic patients with Korsakoff's syndrome was investigated. Various cognitive and memory tests were given to patients with circumscribed frontal lobe lesions, patients with Korsakoff's syndrome, non-Korsakoff amnesic patients, and control Ss. Patients with frontal lobe lesions were not amnesic. Neverthe...