We present a novel approach for the analysis of transcriptomics data that integrates functional annotation of gene sets with expression values in a multivariate fashion, and directly assesses the relation of functional features to a multivariate space of response phenotypical variables. Multivariate projection methods are used to obtain new correlated variables for a set of genes that share a g...

In order to assess functional skills of older adults, both timed up and go (TUG) test and gait speed (GS) test are well validated concerning their predictive capacities. However, the question remains unclear which one of these tests represents better the whole physical performance of older adults. The aim of this study is to determine the more representative test, between TUG and GS, of the who...

For every finitary endofunctor H of Set a rational algebraic theory (or a rational finitary monad) R is defined by means of solving all finitary flat systems of recursive equations over H. This generalizes the result of Elgot and his coauthors, describing a free iterative theory of a polynomial endofunctor H as the theory R of all rational infinite trees. We present a coalgebraic proof that R i...

BACKGROUND Evaluation of the older driver is a difficult task for primary care physicians. We investigated the physician-perceived barriers to assessing older drivers in primary care practice. METHODS Twenty family physicians whose patients had completed a clinical questionnaire and neuropsychological tests participated in one of 2 focus groups. Physicians were asked about barriers to assessi...

Purpose: Pelvic floor muscle dysfunction is a common cause of constipation. This dysfunction does not respond to current treatments of constipation. Thus, it is important to identify this type of dysfunction and the role of these muscles in constipation. The purpose of the present study was to review the previously published studies concerning the role of pelvic floor muscles dysfunction ...

Subject head movements are one of the main practical difficulties with brain functional MRI. A fast, accurate method for rotating and shifting a three-dimensional (3D) image using a shear factorization of the rotation matrix is described. Combined with gradient descent (repeated linearization) on a least squares objective function, 3D image realignment for small movements can be computed as rap...

Background Cardiovascular Magnetic Resonance (CMR) is recognised as the gold standard technique for the assessment of cardiovascular function in adults. In children, image quality is dependent on compliance with motion control and breath-hold instructions. Inability to maintain repeated breath-holds in a consistent phase of respiration can result in respiratory misregistration errors. There is ...

The Toronto Extremity Salvage Score (TESS) is widely used for the functional assessment of patients following surgery for musculoskeletal tumours. The aim of this study was to determine if there are gender and/or age-specific changes, unrelated to surgery, that may influence this score and the appropriateness of the questions. The TESS for lower limb was carried out in two different countries t...

Notwithstanding the fact that many British Physicians have recourse to "suggestion" in the treatment of functional disorder, yet few are openly willing to admit that psychotherapy has played a part in their methods. Such reticence is doubtless largely the outcome of a very natural dread of being placed in the same category with quacks and imposters (styling themselves spiritualists), who bring ...

Objective. The effectiveness of an individualized and everyday approach to cognitive rehabilitation for schizophrenia was examined in a case study. Method. After cognitive and functional assessment, concrete objectives were targeted for the person's everyday complaints. Strategies were constructed based on an analysis of the cognitive profile, daily life functioning, and processes involved in a...