نتایج جستجو برای: functional motifs
تعداد نتایج: 607535 فیلتر نتایج به سال:
Discovery of transcription factor binding sites is a much explored and still exploring area of research in functional genomics. Many computational tools have been developed for finding motifs and each of them has their own advantages as well as disadvantages. Most of these algorithms need prior knowledge about the data to construct background models. However there is not a single technique that...
Uncovering the cis-regulatory logic of developmental enhancers is critical to understanding the role of non-coding DNA in development. However, it is cumbersome to identify functional motifs within enhancers, and thus few vertebrate enhancers have their core functional motifs revealed. Here we report a combined experimental and computational approach for discovering regulatory motifs in develop...
Linear motifs are short, evolutionarily plastic components of regulatory proteins and provide low-affinity interaction interfaces. These compact modules play central roles in mediating every aspect of the regulatory functionality of the cell. They are particularly prominent in mediating cell signaling, controlling protein turnover and directing protein localization. Given their importance, our ...
MOTIVATION Function inference from structure is facilitated by the use of patterns of residues (3D motifs), normally identified by expert knowledge, that correlate with function. As an alternative to often limited expert knowledge, we use machine-learning techniques to identify patterns of 3-10 residues that maximize function prediction. This approach allows us to test the assumption that resid...
Clothing decoration is one of the plastic arts that aim to give clothes a distinct artistic value reflects geographical, social, economic, professional and environmental reality many countries world. If we look at in clothes, find it life, heritage culture peoples. The main research problem lack researches combines traditional motifs two different civilizations, accordingly questions are: What ...
We have analyzed the functional effect of site-directed mutations and deletions in the copper-binding domain of ATP7B (the copper transporting P-type ATPase defective in Wilson disease) using a yeast complementation assay. We have shown that the sixth copper-binding motif alone is sufficient, but not essential, for normal ATP7B function. The N-terminal two or three copper-binding motifs alone a...
Pre-historic pottery investigating is one of the sources that provide a lot of information about the life and art of that time. Among Iranian arts, Pottery is of a greater antiquity, originality and importance and represents people’s culture, beliefs and traditions more than any other art. After basket weaving, pottery has been the first lasting art of mankind. By investigating earthenware moti...
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