Human coagulation factor V (FV), a non-enzymatic cofactor of the prothrombinase complex, is required for the rapid generation of thrombin. FV deficiency is a rare autosomal recessive bleeding disorder. We describe two novel mutations, Tyr91Asn and Asp2098Tyr, found in two probands with a residual FV activity of 51% and 4%, respectively. Modelling and structural analysis of these mutations were ...

A high intake of fruit and vegetables (FV) has been shown to be associated with reduced risk of a number of chronic diseases, including CVD. This review aims to provide an overview of the evidence that increased FV intake reduces risk of CVD, focusing on studies examining total FV intake. This evidence so far available is largely based on prospective cohort studies, with meta-analyses demonstra...

We have constructed a series of "synthetic" target cell lines for an analysis of the specificity of anti-Friend virus (FV) CTL. Our results show that murine H-2 genes and individual retroviral genes can be stable expressed in Fisher rat embryo (FRE) cells, and that their products have the potential to form target structures recognized by mouse CTL. Cells expressing H-2Db and either the env or g...

OBJECTIVE To evaluate the impact of activities promoting the consumption of fruit and vegetables (FV) in the workplace. METHODS Intervention study with historical control group conducted in a public company in Rio de Janeiro, Southeastern Brazil, between 2007 and 2009. It consisted of three stages: (a) baseline, which included the characterization of both the company studied and the one respo...

To explore the effect of fruit and vegetable (FV) juice on biomarkers of oxidative damage and antioxidant gene expression in rats, 36 adult male Wistar rats were randomly divided into control, low FV juice dosage or high FV juice dosage treatment groups. The rats were given freshly extracted FV juice or the same volume of saline water daily for five weeks. After intervention, serum and tissues ...

Little is known about the association between acculturation and fruit and vegetable (FV) consumption among older Mexican-American (MA) women. Environmental and lifestyles changes experienced by immigrants to the United States may markedly affect their diet and health and increase their risk for chronic diseases. Our objectives were to: 1) describe FV consumption by ethnicity, acculturation, and...

Techniques that allow the selective stimulation of the erythropoietin-responsive cell population in mice with suppressed multipotential hemopoietic stem cells were used to identify (1) the in vivo target cell transformed by Friend virus (FV) into a tumor colony-forming unit and (2) a target cell for FV replication in vivo. Plethoric mice with busulphan-induced reductions in stem cell population...

−− It’s a fact that functional verification (FV) is paramount within the hardware’s design cycle. With so many new techniques available today to help with FV, which techniques should we really use? The answer is not straightforward and is often confusing and costly. The tools and techniques to be used in a project have to be decided upon early in the design cycle to get the best value for these...

Definition 1.1. Formally, a protocol P is a rooted binary tree with each internal node v labelled by either “A” or “B” and two out-edges, one labelled 0 and the other labelled 1. Each leaf has an output label (typically in {0, 1}. There is a function fv associated with node v; if v is labelled A then fv : X → {0, 1} and if v is labelled B then fv : Y → {0, 1}. The bit sent at node v is sent by ...

Factor V (FV) Leiden is the most common genetic defect found in persons of European descent with venous thromboembolism.1 The 1691G.A transition determines the R506Q substitution.2 This suppresses a cleavage site for activated protein C (APC) on FVa, resulting in resistance to APC in a functional coagulation-based assay.3 FV Leiden accounts for over 90% cases of APC resistance, but this phenome...