Heme-iron oxidoreductases operating through the high-valent FeIVO intermediates perform crucial and complicated transformations, such as oxidations of unreactive saturated hydrocarbons. These enzymes share same Fe coordination, only differing by axial ligation, e.g., Cys in P450 oxygenases, Tyr catalases, His peroxidases. By examining ?200 heme-iron proteins, we show that protein hosts exert hi...

Aim Gamma-band auditory steady-state response (ASSR) is a neurophysiologic index that increasingly used as translational biomarker in the development of treatments neuropsychiatric disorders. While gamma-band ASSR generated by distributed networks highly interactive temporal and frontal cortical sources, majority human studies using electroencephalography (EEG) highlight activity from only sing...

GABA is a putative inhibitory neurotransmitter in adult mammalian visual cortex but also has been implicated as playing a crucial role in cortical information processing during development. In order to understand better the role of GABA during primate visual cortex development, we have examined the time course of GABAA and GABAB receptor ontogenesis in 18 Macaca nemestrina monkeys ranging from ...

AIMS Signalling through the Wnt pathway is integrally associated with colon carcinogenesis. Although activating mutations in the genes for adenomatous polyposis coli (APC) and beta-catenin are clearly associated with colon cancer, less is understood about the role of the upstream secreted ligands (Wnts) and their receptors (frizzled, Fz) in this process. In other systems, increased Wnt signalli...

In this online section, we consider an information structure in which both article quality and author signals are continuously distributed. The structure is identical to the one presented in Leslie (2005). This section, therefore, illustrates how the main result in the paper—that journal quality is maximized through a combination of both fees and delays when authors have heterogeneous cost pref...

A radiation hard Si detector is used in the new CMS tracker at HL-LHC. It has been observed that n-MCz and n-Fz as a material can be for micro strip detector. The design this should simulated optimized to get high CCE. In order understand charge collection behavior of n-MCz/n-FzSi detector, it required simulate compare damage effects mixed irradiated neutron n-FzSi equipped with metal overhang ...

High-resistivity p-type silicon has emerged as one of the most promising materials for the finely segmented detectors to be used in particle physics experiments where high levels of radiation damage are expected. Beside the standard high-purity float-zone (FZ) silicon, relatively high-resistivity magnetic Czocharlski (MCz) is now available from industry. This material has been proposed as possi...

Planar cell polarity (PCP) has been demonstrated in the epithelium of organisms from flies to humans. Recent research has revealed that the planar organization of cells requires a conserved set of genes, known as the PCP genes. Tbe PCP proteins Frizzled (Fz) and Dishevelled (Dsh) function as key players in PCP signalling. Although Fz and Dsh are also involved in Wingless (Wg)/Wnt signalling, th...