The aim of the present work was to examine possible genetic risk factors related to the occurrence of cerebrovascular disease (CVD) in Brazilian population, the frequency of β(S)-globin gene haplotypes and co-inheritance with α-thalassemia (-α(3.7kb)) and single nucleotide polymorphism of methylenetetrahydrofolate reductase (MTHFR-C677T), Factor V Leiden (FV-G1691A) and prothrombin (PT-G20210A)...

ELVIRA GRANDONE,* MAURIZIO MARGAGLIONE,* DONATELLA COLAIZZO,* GIUSEPPE PAVONE,° DARIO PALADINI,° PASQUALE MARTINELLI,° GIOVANNI DI MINNO* *Unità di Aterosclerosi e Trombosi and Obstetrics and Gynecology Department, IRCCS “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo (FG); °Obstetrics and Gynecology Department, Università “Federico II”, Naples, Italy Correspondence: Elvira Grandone, MD, ...

Background: Thrombophilia is a main predisposition to thrombosis due to a procoagulant state. Several point mutations play key roles in blood-clotting disorders, which are grouped under the term thrombophilia. These thrombophilic mutations are methylenetetrahydrofolate reductase (MTHFR, C677T, and A1298C), factor V Leiden (G1691A), prothrombin gene mutation (factor II, G20210A), and plasminogen...

Background and Aims: To date, several factors have been reported in recurrent miscarriage. Genetic mutations are the most important causative factors in women. Fetal thrombotic vasculopathy is a new described placental alteration with varying degrees of involvement and often associated with adverse prenatal outcomes. The diagnosis is made histologically and so is postnatal, which makes it a cha...