Glucose-6-phosphate dehydrogenase (G6PD) is a potentially pathogenic inherited enzyme abnormality and, similar to other human red blood cell polymorphisms, is particularly prevalent in historically malaria endemic countries. The spatial extent of Plasmodium vivax malaria overlaps widely with that of G6PD deficiency; unfortunately the only drug licensed for the radical cure and relapse preventio...

BackgroundGlucose-6-phosphate dehydrogenase (G6PD) deficiency is a genetic disorder caused by structural abnormality in the enzyme. G6PD most prevalent among African, Asian, and Mediterranean people. This study aimed to investigate how African neonates with jaundice.MethodsThe public sources, such as PubMed, Science Direct, Google Scholar, Africa Journal Online were searched for articles that r...

glucose-6-phosphate dehydrogenase (g6pd) deficiency is the most important disease of the hexose monophosphate pathway. deficiency of this enzym can lead to hemolysis of red blood cells. our aim was to study the prevalence of g6pd deficiency in relation to neonatal jaundice. we studied 456 clinically icteric neonates laboratory investigations included determination of direct and indirect serum b...

In the Amazon, treatment for Plasmodium vivax is chloroquine plus primaquine. However, this regimen limited due to risk of acute hemolytic anemia in glucose-6-phosphate dehydrogenase deficiency. Primaquine a prodrug that requires conversion by CYP2D6 enzyme be effective against malaria. A series cases were performed at an infectious diseases reference hospital Western Brazilian Amazon. The STAN...

BACKGROUND There is a strong correlation between glucose-6-phosphate dehydrogenase (G6PD) deficiency and neonatal hyperbilirubinemia with a rare but potential threat of devastating acute bilirubin encephalopathy. G6PD deficiency was observed in 4-14% of hospitalized icteric neonates in Pakistan. G6PD c.563C > T is the most frequently reported variant in this population. The present study was ai...

Background: Absence or deficiency in Glucose-6-phosphate dehydrogenase (G6PD) enzyme in patients with G6PD deficiency presents with a wide spectrum of symptoms. This study evaluates the clinical features of acute hemolysis in children with G6PD deficiency. Materials and Methods: Seventy G6PD deficient children younger than 18 years old were included in this cross sectional study in Dastgheib H...

Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme, playing an important role in the redox metabolism of all aerobic cells. It was reported that certain medications, fava beans, and infections can trigger acute hemolytic anemia in patients with G6PD deficiency. An 8-year-old male patient was admitted to the hospital with blood in the urine, headache, dizziness, fatigue, loss of appetite, and...

Background: Human genetic variation is interlinked to genetic drift and gene flow. Interplay amongst these leads to evolution in natural populations. Studies suggest that Glucose-6Phosphate Dehydrogenase (G6PD)-deficient alleles show some signatures of selection. Deficiency in G6PD is the most common enzyme deficiency of human erythrocyte which affects over 400 million people worldwide. There i...

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymatic disorder of red blood cells in humans. It is estimated that about 400 million people are affected by this deficiency. The G6PD enzyme catalyzes the first step in the pentose phosphate pathway, leading to antioxidants that protect cells against oxidative damage. A G6PD-deficient patient, therefore, lacks the ability...