Peripheral tissue injury-induced central sensitization may result from the altered biochemical properties of spinal dorsal horn. However, peripheral nerve injury-induced modification of genes in the dorsal horn remains largely unknown. Here we identified strong changes of 14 channels, 25 receptors and 42 signal transduction related molecules in Sprague-Dawley rat dorsal spinal cord 14 days afte...

The vast majority of inhibitory neurotransmission in the brain is mediated by γ-aminobutyric acid (GABA). It has been detected in approximately 30% of all synapses and acts via ionotropic GABAA receptors, which mediate fast inhibitory neurotransmission, and metabotropic GABAB receptors, which mediate slower inhibitory effects. GABAA receptors (GABAARs) are chloride channels belonging to the Cys...

In the present study, the effects of excitation and inhibition of GABAA and GABAB receptor subtypes on the expression of morphine-induced conditioned place preference (CPP) were investigated. For this purpose, male Wistar rats (250-300 g) were used in the experiments. Five days after surgical cannulation in the ventral tegmental area (VTA), different doses of morphine were injected into the ani...