Receptors for the Fc domains of IgG (Fc gamma R) play a critical role in linking humoral and cellular immune responses. The various Fc gamma R genes may contribute to differences in infectious and immune related diseases in various ethnic populations. Polymorphisms of Fc gamma R mainly Fc gamma R IIA, IIB, IIIA, IIIB have been identified as genetic factors influencing susceptibility to disease ...

VDJ recombination of T cell receptor and immunoglobulin loci occurs in immature lymphoid cells. Although the molecular mechanisms of DNA cleavage and ligation have become more clear, it is not understood what controls which target loci undergo rearrangement. In interleukin 7 receptor (IL-7R)alpha-/- murine thymocytes, it has been shown that rearrangement of the T cell receptor (TCR)-gamma locus...

T-lymphocytes (LYs) from normal and IFN-gamma knockout mice were activated by anti-CD3 and anti-CD28 antibodies and cultured in inserts in the presence of interleukin (IL)-12 (IL-12-activated LYs) or not (activated LYs). Their ability to modulate the genetic programs of two tumor lines growing at the bottom of transwells was evaluated. cDNA gene expression array, reverse transcription-PCR, and ...

The bremsstrahlung flux-averaged cross-sections $\langle{\sigma(E_{\rm{\gamma max}})}\rangle$ and the per equivalent photon max}})_{\rm{Q}}}\rangle$ were measured for photonuclear multiparticle reaction $^{27}\!\rm{Al}(\gamma,\textit{x}; \textit{x} = {^{3}\rm{He}} + pd 2pn)^{24}\rm{Na}$ at end-point energies ranging from 40 MeV to 95 MeV. experiments performed using beam NSC KIPT electron linea...

We generalize the dispersive approach to axial anomaly by A. D. Dolgov and V. I. Zakharov [Nucl. Phys. B27, 525 (1971).] a non-Abelian case with arbitrary photon virtualites. derive sum rule for singlet current obtain ${\ensuremath{\pi}}^{0},\ensuremath{\eta},{\ensuremath{\eta}}^{\ensuremath{'}}\ensuremath{\rightarrow}\ensuremath{\gamma}{\ensuremath{\gamma}}^{*}$ transition form factors. Using ...

Synthesis of accurately initiated transcripts has been reconstituted with RNA polymerase II and a set of five transcription factors purified from rat liver. In addition to three previously identified factors alpha, beta gamma, and delta (Conaway, R. C., and Conaway, J. W. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 7356-7360), transcription in the reconstituted liver system requires two novel fa...

introduction: different environmental factors such as drugs, ionizing radiation, etc can induce apoptosis.in the present study the effects of dose- rate and post-irradiation incubation time on gamma radiation inducedapoptosis in human breast carcinoma cell line (t-47d) (invasive ductal carcinoma) was investigated. material and methods: the t-47d cells were cultured in t25 flasks and during log ...

As is well-known, the requirement that gamma ray bursts (GRB’s) be optically thin to high energy photons yields a lower limit on the Lorentz factor (γ) of the expansion. In this paper, we provide a simple derivation of the lower limit on γ due to the annihilation of photon pairs, and correct the errors in some of the previous calculations of this limit. We also derive a second limit on γ due to...

OBJECTIVE To elucidate the mechanism of the reported association between serum gamma-glutamyl transferase (GGT) activity and cardiovascular mortality. METHODS Cross-sectional analysis of the relationship between serum GGT activity and the risk factors for cardiovascular disease was performed. PATIENTS AND MATERIALS Middle-aged Japanese male personnel of the Self-Defense Forces who underwent...