BACKGROUND Our previous studies suggest that serum gamma-glutamyltransferase (GGT) activity may be related to oxidative stress, supporting findings of experimental studies. To further examine the role of GGT in relation to oxidative stress, we investigated the association between serum carotenoids and tocopherols, which have antioxidant properties, and serum GGT. METHODS Study participants we...

BACKGROUND While adult populations have been well described in terms of nutritional status, such as the concentration of nutrient biomarkers, little work has been done in healthy paediatric populations. OBJECTIVE The primary objective of this analysis was to explore the determinants of plasma micronutrients in a group of healthy infants and children. DESIGN The Diabetes Autoimmunity Study i...

OBJECTIVE The intake of antioxidants was studied for its ability to predict type 2 diabetes. RESEARCH DESIGN AND METHODS A cohort of 2,285 men and 2,019 women 40-69 years of age and free of diabetes at baseline (1967-1972) was studied. Food consumption during the previous year was estimated using a dietary history interview. The intake of vitamin C, four tocopherols, four tocotrienols, and si...

OBJECTIVE To examine associations of biomarkers of nutrient intake with overall diet quality. SUBJECTS A convenience sample of 102 healthy postmenopausal women in Seattle, Washington (USA). DESIGN AND METHOD Participants attended a study centre where they provided fasting blood specimens and completed a 122-item validated food-frequency questionnaire (FFQ). Data from the FFQ were used to ca...

Data on dietary exposure to vitamin E by plasma or adipose tissue concentrations of alpha-tocopherol (alpha-T) in observational studies have failed to provide consistent support for the idea that alpha-T provides women with any protection from breast cancer. In contrast, studies indicate that alpha, gamma, and delta-tocotrienols but not alpha-T have potent anti-proliferative effects in human br...

To investigate the relationship between serum micronutrients and the subsequent risk of oral and pharyngeal cancer, a nested case-control study was conducted within a cohort of 25,802 adults in Washington County, MD, whose blood samples were collected in 1974 and stored at -70 degrees C for subsequent assays. The serum levels of nutrients in 28 individuals who developed oral and pharyngeal canc...

The relationship between serum concentrations of carotenoids, tocopherols and retinol and the consumption of cigarettes, alcohol and foods was investigated in 835 healthy inhabitants (aged 35-79 years) of a rural area of Hokkaido. Serum concentrations of beta-carotene (BC), alpha-carotene (AC), lycopene (LY), beta-cryptoxanthin (BX), zeaxanthin (including lutein, ZX), canthaxanthin (CX) and bet...

Abstract Background Direct measurement of the bioavailable α-tocopherol content presents a significant analytical challenge and requires chiral separation stereoisomers. Objective The objective study was to validate an method for analysis stereoisomers in infant formulas dairy products. Method Samples were saponified at elevated temperature lipophilic components extracted into organic solvent, ...

A study involving 360 farrowings over a five-parity period evaluated the effects of dietary vitamin E on sow reproductive performance and the subsequent effects on serum, colostrum, and milk tocopherol contents. The 2 x 3 split-split-plot experiment was conducted at two locations that differed in the type of facility (indoor gestation pens/farrowing crates [IP/FC] or outside gestation lots/indo...