In Japan, the continual rise in the number of people moving to Tokyo is causing various economic and social problems, including high o&e rents, housing shortages, trafic jams, and obligatory long-distance commuting. To try to curb this concentration in Tokyo, government agencies and private companies have set up projects and research groups to study distributing ofice space. We have been studyi...

Game jams are social events involving the integration of enthusiasts from various game making disciplines (e.g. programming, art, design) to make games under constraints, such as a short fixed time (Goddard et al. 2014) and a common theme (Fowler et al 2013). Research on game jams has suggested that they have the potential to provide an effective and focused experience and that participants gai...

in order to study the response of different chickpea genotypes to drought stress and determination of drought resistant genotypes, this experiment was conducted with 18 kabouli type chickpea genotypes including of susceptible check (ilc 3279) and local check (jam). the experiment was performed in a rbc design with three replications under rained and irrigated conditions during 2001-2 cropping s...

Planar spindle orientation in polarized epithelial cells depends on the precise localization of the dynein-dynactin motor protein complex at the lateral cortex. The contribution of cell adhesion molecules to the cortical localization of the dynein-dynactin complex is poorly understood. Here we find that junctional adhesion molecule-A (JAM-A) regulates the planar orientation of the mitotic spind...

RATIONALE Besides their essential role in hemostasis, platelets also have functions in inflammation. In platelets, junctional adhesion molecule (JAM)-A was previously identified as an inhibitor of integrin αIIbβ3-mediated outside-in signaling and its genetic knockdown resulted in hyperreactivity. OBJECTIVE This gain-of-function was specifically exploited to investigate the role of platelet hy...

Breaching endothelial cells (ECs) is a decisive step in the migration of leukocytes from the vascular lumen to the extravascular tissue, but fundamental aspects of this response remain largely unknown. We have previously shown that neutrophils can exhibit abluminal-to-luminal migration through EC junctions within mouse cremasteric venules and that this response is elicited following reduced exp...

In this study, the interactions of enterohemorrhagic Escherichia coli (EHEC) O157 strains with human ileocecal (HCT-8) epithelial cells and HEp-2 cells were examined. EHEC adhered to, but did not invade, HCT-8 cells by the localized adherence mechanism and a heretofore unrecognized pattern which we called log jam. The log jam formation was (i) not observed on HEp-2 cells, (ii) independent of th...

Exploring the role of junctional adhesion molecules (JAMs) has proven to be varied and controversial. The purpose of this review is to discuss the new and exciting roles of these IgSF molecules and how they have evolved to contribute to diverse functions from development to inflammation. In particular, recent research has focused on JAM subfamily members JAM-A, -B, and -C with newly described r...

Evaluation of biomarkers of arterial hypertension (AH) could be considered to be useful as early, more reliable and accurate diagnostic indicators for AH than simply measuring of blood pressure (BP) in routine clinical practice, especially at early stages of hypertension. For instance, an increased level of a soluble protein junctional adhesion molecule-A (JAM-A) was previously found to be asso...