نتایج جستجو برای: gap junction protein beta 2
تعداد نتایج: 3688275 فیلتر نتایج به سال:
Gap junction assembly in the preimplantation mouse embryo is a temporally regulated event, beginning a few hours after the third cleavage during the morphogenetic event known as compaction. Recently, we demonstrated that both mRNA and protein corresponding to connexin43, a gap junction protein, accumulate through preimplantation development beginning at least as early as the 4-cell stage. Using...
The spatio-temporal appearance and distribution of proteins forming the intercalated disc were investigated in adult rat cardiomyocytes (ARC). The 'redifferentiation model' of ARC involves extensive remodelling of the plasma membrane and of the myofibrillar apparatus. It represents a valuable system to elucidate the formation of cell-cell contact between cardiomyocytes and to assess the mechani...
The expression of three different gap junction transcripts, or, (Cx43), B~ (Cx39, and B2 (Cx26) was examined in several organs during pregnancy in the rat. In all of the organs that were examined-uterus, ovary, heart, and l iverthere was a strong correlation between levels of gap junction mRNA and gap junction antigens that were detected at different stages of pregnancy. A striking change in o~...
Introduction: The most common sensory disorder, hearing loss, may result from genetic causes. Various inheritance patterns exist, such as X-linked, autosomal dominant, recessive, and mitochondrial. However, the underpinnings of racial distinctiveness regional variation were incompletely understood. To fully evaluate ethnic specificity gap junction protein beta 2 (GJB2) tectorin alpha (TECTA) mu...
Keratoderma-hypotrichosis-leukonychia totalis syndrome (KHLS) is an extremely rare, autosomal-dominant disorder characterized by severe skin hyperkeratosis, congenital alopecia and leukonychia totalis. The genetic defect underlying KHLS remained undetermined. By performing whole-exome sequencing in a family with KHLS, we identified a heterozygous mutation (c.23G>T [p.Gly8Val]) in GJA1, which co...
The fate of gap junctions in dissociated adult myocytes, maintained for up to 22 hours in culture medium, was investigated by semiquantitative analysis of thin sections and by freeze-fracture electron microscopy. Gap junctions in the dissociated myocyte are intact bimembranous structures seen either as invaginated surface-located structures or as annular profiles in the cytoplasm. Surface-locat...
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