Cervical cancer is the fourth most lethal women's cancer worldwide. Current treatments against cervical cancer include surgery, radiotherapy, chemotherapy, and anti-angiogenic agents. However, despite the various treatments utilized for the treatment of cervical cancer, its disease burden remains a global issue. Persistent infection of human papillomavirus (HPV) has been identified as an essent...

Chemoprevention agents are an emerging new scientific area that holds out the promise of delaying or avoiding a number of common cancers. These new agents face significant scientific, regulatory, and economic barriers, however, which have limited investment in their research and development (R&D). These barriers include above-average clinical trial scales, lengthy time frames between discovery ...

The test of whether a proposed mandatory vaccination program is constitutional needs updating. Jacobson v. Massachusetts, decided by the U.S. Supreme Court over a century ago, laid out the proper reasoning and concerns to be addressed when determining the legality of mandatory vaccinations, but its analysis is tailored to the extreme case of the smallpox epidemic. As more vaccinations are creat...

The publisher of Canada’s largest circulation daily, the Toronto Star, has acknowledged that the paper mishandled a story that suggested a link between the human papillomavirus (HPV) vaccine Gardasil and serious illness and deaths. However, speaking on Canadian Broadcasting Corporation (CBC) Radio’s news program As It Happens on 11 February, the paper’s publisher, John Cruickshank, faulted the ...

1798 www.thelancet.com Vol 387 April 30, 2016 Human papillomavirus (HPV) is the most common sexually transmitted infection. It aff ects 80% of the population, with the initial infection usually occurring between 15 and 24 years of age. Persistent infection with high-risk oncogenic HPV genotypes, primarily types 16 and 18, is the cause of almost all cervical cancers. HPV is also thought to cause...

Background: The proper understanding of a true risk from vaccines is crucial for avoiding unnecessary adverse reactions (ADRs). However, to this date no solid tests or criteria have been established to determine whether adverse events are causally linked to vaccinations. Objectives: This research was carried out to determine whether or not some serious autoimmune and neurological ADRs following...