Background: Opioid peptides and their receptors are present in the majority of body tissues including gastrointestinal tract.  Heroin is one of the opioid derivatives that abuse increasingly today.  So far, there is no study on the effect of acute heroin administration on gastric acid and pepsin secretion. Objective:  To define the effect of the acute heroin consumption on basal and vagal-stimu...

BACKGROUND Zingiber zerumbet Smith is a perennial herb, broadly distributed in many tropical areas. In Malaysia, it's locally known among the Malay people as "lempoyang" and its rhizomes, particularly, is widely used in traditional medicine for the treatment of peptic ulcer disease beyond other gastric disorders. AIM OF THE STUDY The aim of the current study is to evaluate the gastroprotectiv...

Objective HER-2/neu gene is overexpressed in diverse human cancers and studies suggest a role of its product – p185 protein – in tumor progression by specifically promoting the invasive capacity of tumor cells. Our aim was to evaluate HER-2/neu content in resectable gastric cancer in this geographical region and assess the relationship between p185 expression and clinicopathologic tumor paramet...

BACKGROUND & OBJECTIVES Most of the non-steroidal anti-inflammatory drugs (NSAIDs) including aspirin cause gastric ulcer. In order to study the gastroprotective effect of Cissus quadrangularis extract (CQE), this study was undertaken on aspirin-induced ulcerogenesis in pyloric ligated (ASP-PL) model in rats. METHODS To assess the possible antiulcer effect of CQE, lesion index, gastric secreti...

The gastric ulcerogenic effect of the glucocorticoid, prednisolone, was studied in albino rats. Shay operation in forestomachectomized rats with intact adrenals induced acute gastric ulcers in the corpus, whereas adrenalectomy prevented the development of gastric ulcers in another group of forestomachectomized Shay rats. Only superficial erosion of gastric epithelium was noticed in 66.67% of th...

Hydrogen sulfide (H2S) has been shown to protect the gastric mucosa through several protective mechanisms but till now its effect on mRNA expression of sodium bicarbonate cotransporter 1 (NBC1), trefoil factor1 (TFF1) and trefoil factor2 (TFF2) was not investigated. This study was aimed to evaluate the effect of H2S on mRNA expression of NBC1, TFF1 and TFF2 in rat gastric ...

Applied potential tomography (APT) is a new, non-invasive technique that can yield sequential images of changes in the resistivity of gastric contents. Studies were performed to investigate the application of APT to measure gastric acid secretion. Experiments in 20 normal volunteers showed that changes in gastric resistivity were closely correlated with changes in the volume (r = 0.80), the aci...

BACKGROUND Piper betle Linn. (Piperaceae) is used as a remedy for gastric ulcers in traditional medicinal systems in Sri Lanka. However, the gastroprotective activity has never been proven scientifically using betel leaves grown in Sri Lanka. OBJECTIVE To evaluate the gastroprotective activity of hot aqueous extract (HAE) and cold ethanolic extract (CEE) of P. betle in rats as the experimenta...

The present study aims to distinguish the effect of tocotrienol on an important gastric protective factor, prostaglandin E2 (PGE2), in stress-induced gastric injury. Twenty-eight Wistar rats were divided into four groups of seven rats each. Two control groups were fed commercial rat diet, and two treatment groups were fed the same diet but with additional dose of omeprazole (20 mg/kg) or tocotr...

The aim of this study was to investigate the impacts of positive acceleration (+Gz) on the gastric mucosal tissues in cases of acute gastric mucosal injury and to explore the role of oxygen free radicals. Thirty Sprague Dawley rats were randomly divided into the absolute ethanol control group (A group), absolute ethanol +5Gz group (B group), absolute ethanol +10Gz group (C group). Following cen...