This paper presents evidence for the existence in extracts from porcine non-antral gastric tissue of a peptide capable of causing substantial rises of plasma immunoreactive gastrin levels in a dose dependent manner and of stimulation of gastric acid and pepsin secretion. Obtained data show that the peptide is basic and that its gastrin releasing properties are at least partially resistant to at...

Determination of the serum pepsinogen level is simple and the method gives consistent results. The serum pepsinogen level remains steady when the stomach is actively secreting pepsin. Age and sex do not greatly affect the serum pepsinogen concentration. Serum pepsinogen levels can be correlated with the histological appearances of the gastric mucosa. The parietal cells appear to be more sensiti...

THE PEPTIC ZYMOGENS OF HUMAN GASTRIC MUCOSA HAVE BEEN STUDIED IN THE PAST BY THREE DIFFERENT TECHNIQUES: phosphate-gradient chromatography on a column of DEAE-cellulose, chloride-gradient chromatography on DEAE-cellulose and agar-gel electrophoresis. These techniques have given different results, each suggesting the presence of a different number of pepsin zymogens in human gastric mucosa. In t...

Gastric acid secretion, pepsin secretion, and fasting serum gastrin levels were measured in 23 patients with duodenal ulcer disease, divided into three groups which received either cimetidine 800 mg daily, cimetidine 1600 mg daily, or ranitidine hydrochloride 300 mg daily for eight weeks. Pentagastrin tests were carried out at intervals both before and after treatment. Each dose of cimetidine r...

The pepsinogens of human gastric mucosa have been the subject of several studies using electrophoretic and chromatographic techniques (Uriel, 1960; Seijffers, Segal, and Miller, 1963; Tang and Tang, 1963; Kushner, Rapp, and Burtin, 1964; Rapp, Aronson, Burtin, and Grabar, 1964; Hanley, Boyer, and Naughton, 1966; Taylor, 1968; Samloff, 1969); it has been shown that gel electrophoresis is superio...

The gastric acid, pepsin, and secretory volume output in response to a mixed meal were measured in six patients with Zollinger-Ellison syndrome caused by a gastrin-producing tumour proved subsequently at surgery. The patients were all normocalcaemic, and none had previous abdominal surgery. In four of the six patients, ingestion of the meal markedly inhibited the gastric secretory output, which...

Sweet potato proteins have been shown to possess antioxidant and antidiabetic properties in vivo. The ability of a protein to exhibit systemic effects is somewhat unusual as proteins are typically susceptible to digestive enzymes. This study was undertaken to better understand how digestive enzymes affect sweet potato proteins. Two fractions of industrially processed sweet potato peel, containi...

The mucosal defensive mechanisms of the esophagus against acid and pepsin remain to be elucidated. In the present study, we investigated the contribution of the salivary mucin in maintaining the integrity of the esophageal mucosa. When an everted esophageal sac, isolated from normal rat, was treated with N-acetyl-l-cysteine, a mucolytic agent, the amount of glycoprotein in the gel layer adheren...

Allen, Adrian, and Gunnar Flemström. Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin. Am J Physiol Cell Physiol 288: C1–C19, 2005; doi:10.1152/ajpcell.00102.2004.—Secretion of bicarbonate into the adherent layer of mucus gel creates a pH gradient with a near-neutral pH at the epithelial surfaces in stomach and duodenum, providing the first line of mucosal protection...