Recent developments in the epidemiology, staging, and treatment of esophageal and gastroesophageal junction cancers have led to significant changes in the way these malignancies are managed. Although a relationship between gastroesophageal reflux disease and esophageal cancer has been demonstrated, antireflux surgery has been shown to have no preventive effect with regard to the development of ...

Transoral incisionless fundoplication (TIF) has been used for endoscopic treatment of gastroesophageal reflux disease (GERD). TIF using the EsophyX device system (EndoGastric Solutions) was designed to create a full-thickness valve at the gastroesophageal junction through the insertion of multiple fasteners; it improves GERD, reduces proton pump inhibitor use, and improves quality of life. Alth...

Pseudomalignant erosion is a diagnostic pitfall for pathologists in the differential diagnosis of malignant neoplasms. Here, we present a challenging case of a biopsy specimen from the eroded head of a polyp at the esophagogastric junction. A malignant neoplasm could not be ruled out due to the presence of bizarre stromal cells. A second biopsy performed after the administration of a proton pum...

30 31 Gastroesophageal reflux disease (GERD) is one of the most common problems in clinical 32 practice today. It is widely believed that functional and structural abnormalities of the 33 gastroesophageal junction as well as an abnormal exposure to gastroduodenal contents are the 34 main contributors to its pathogenesis. Novel findings of the inflammatory process in GERD 35 suggest a far more c...

INTRODUCTION Disorders affecting the oropharynx and esophagus are relatively common in dogs, and are typically associated with dysphagia. Despite the frequency of this problem, the diagnosis of disorders affecting the oropharyngeal, esophageal or gastroesophageal phase of swallowing can be extremely challenging, and warrant a thorough physical examination, followed by clinical observations of t...

Gastroesophageal reflux disease (GERD) is one of the most common problems in clinical practice today. It is widely believed that functional and structural abnormalities of the gastroesophageal junction as well as an abnormal exposure to gastroduodenal contents are the main contributors to its pathogenesis. Novel findings of the inflammatory process in GERD suggest a far more complex process inv...

Isolated metastases from gastric adenocarcinoma to the spleen are very infrequent. Usually, there are multiple metastases from gastric cancer, and isolated splenic metastases are very rare [Lam and Tang: Arch Pathol Lab Med 2000;124:526-530] because of certain anatomical and physiological characteristics (e.g., angulation between the splenic artery and celiac trunk, paucity of afferent lymph fl...