Umbilical metastasis is one of the main characteristic signs of extensive neoplastic disease and is universally referred to as Sister Mary Joseph's nodule. It indicates neoplasm of inner organs mostly located in the gastrointestinal tract or the pelvis. However, in approximately 15-30% the primary tumor remains occult. In most cases, Sister Mary Joseph's nodule appears as an early and sometimes...

Primary mucinous adenocarcinoma of the appendix is a rare gastrointestinal malignancy. Fistulous tract formation is a complication that is cited in literature. An 85-year-old man with multiple comorbidities presented with several weeks of persistent non-bloody diarrhea. Laboratory work-up was non-diagnostic. Abdominal imaging with barium contrast showed an enterocolonic fistulous tract extendin...

Follicular dendritic cells (FDC) are non-lymphoid, non-phagocytic accessory cells of the immune system and these cells are essential for antigen presentation and regulation of the reactions in germinal centers. Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm that shows a low-to-intermediate malignant potential. The most commonly involved sites are the lymph nodes, but FDCS may also ...

INTRODUCTION Gastrointestinal stromal tumors are a rare neoplasm exhibiting, in most cases, mutations of c-kit. Imatinib mesylate is the standard treatment for patients who have advanced gastrointestinal stromal tumors. Although the response rate in patients treated with imatinib mesylate in prospective clinical studies is above 50%, a complete response is very rare. We report the case of a pat...

Gastrointestinal stromal tumors are the most common mesenchymal tumors of the gastrointestinal tract. Until today, there have been few markers specific for the tumor. This has complicated the differential diagnosis of the neoplasm from tumors of smooth muscle origin. Recently, the proto-oncogene c-kit has been shown to be a very relevant marker as it almost invariably is expressed in gastrointe...

In screening endoscopy, biopsies for suspicious malignant lesions often show a diagnosis of regenerative atypia which makes it difficult to make clinical decisions because ambiguous pathologic characteristics. Therefore, we performed analysis find discriminating factors true gastric neoplasms among found in endoscopy. We reviewed medical records and endoscopic findings individuals with forcep u...

results: among 11 patients who underwent surgery consisted of eight males and three females. their metastasis originated from testis tumors (n = 5), renal cell carcinoma (rcc; n = 4), bladder tumor (n = 1), and prostate cancer (n = 1). their mean age was 41.27 years (range, 21-67). the mean age of the patients with rcc and testis tumor at the time of diagnosing metastasis was 54 and 24.8 years,...

Fluoropyrimidines (FP) are the mainstay treatment of many neoplasms, especially gastrointestinal (GI) tract cancers. Its metabolism is guaranteed by enzyme dihydropyrimine dehydrogenase (DPD), which in turn encoded DPYD gene. DPD deficits carry an increased risk FP toxicity, such as stomatitis, diarrhoea, neutropenia and neurotoxicity, it affects about 3-9% Caucasian population. The aim this st...

A gastrointestinal stromal tumor (GIST) is a rare malignancy, accounting for only 0.1% to 3% of all (GI) malignancies. Although GISTs are the most common mesenchymal GI tract, they primarily found within stomach, with rectal rarely reported. They may present bleeding, constipation, pain, or palpable mass while some incidentally. The incidence has been on rise, possibly due advancements in diagn...