BACKGROUND Malignant gastrointestinal stromal tumors (GIST) are rare mesenchymal tumors originating in the wall of the gastrointestinal tract. Myogenic gastrointestinal stromal tumor, a distinctive morphologic variant is characterized by an unusually prominent myxoid stromal background. CASE PRESENTATION We report a case of myxoid variant of GIST in a 42 years old woman presenting as an epiga...