Antiepileptic drugs (AEDs) protect against seizures through interactions with a variety of cellular targets. By affecting the functional activity of these targets, AEDs suppress abnormal hypersynchronous activity in brain circuits, leading to protection against seizures. The actions on these targets can be categorized into four broad groups: (i) modulation of voltage-gated ion channels, includi...

We propose a time-gated-single-pixel-camera as promising sensor for image-free object detection automotive application in adverse weather conditions. By combining the well-known principles of time-gating and single-pixel with neural networks, we aim to ultimately detect objects within scene rapidly robustly low-cost sensor. Here, evaluate possible data reduction such system can provide compared...

Background: in radiation treatment of moving targets located in thorax region of patient body, the delivered dose does not match with the planned treatment, resulting in some over and under dosage in the tumor volume, as a function of motion magnitude and frequency. Several efforts have been done to investigate the target motion effects on dose distribution in the target and surrounding normal ...

Background: Aberrant chromosomes can cause azoospermia but little is known about its molecular mechanism. Our aim is to explore any possible genetic defective to explain a given male infertility. Materials and Methods: An azoopsermic male was identified in a 23 years old male. G-banding and FISH confirmed the karyotype as chromosome insertion (18:7) (q22.1; q36.2q21.11). NGS was performed to an...

Organic Thin Film Transistors (OTFT), gated through an aqueous electrolyte, have extensively been studied as sensors in various applications. These water-gated devices are known to work both as electrochemical (Organic ElectroChemical Transistor OECT) and field-effect (Organic Field-Effect Transistor OFET) devices. To properly model and predict the response of water-gated OTFT sensors it is imp...

BACKGROUND Cardiac and respiratory movements cause catheter instability. Lateral catheter sliding over target endocardial surface can lead to poor tissue contact and unpredictable lesion formation. We describe a novel method of overcoming the effects of lateral catheter sliding movements using an electrogram-gated pulsed power ablation. METHODS AND RESULTS All ablations were performed on a th...

New compounds are needed to treat parasitic nematode infections in humans, livestock and plants. Small molecule anthelmintics are the primary means of nematode parasite control in animals; however, widespread resistance to the currently available drug classes means control will be impossible without the introduction of new compounds. Adverse environmental effects associated with nematocides use...

This paper focuses on prototyping pausible and gated In this paper, after presenting an overview on the pausible clock based GALS systems on commercial FPGAs. Pausible clock clock based and gated clock based GALS systems in sections II based GLAS systems use an on-chip clock generator to generate and III, the implementation of GALS on commercial FPGA pausible clock pulses whereas gated clock ba...

introduction: although left ventricular(lv) function parameters measured by gated myocardial perfusion spect (gspect) have been validated, experimental data have revealed that the calculated the lv function parameters using gspect are affected by patient populations as well as particular acquisition and processing conditions. we tried to determine the normal values of gspect in an iranian popul...

introduction: good functional capacity has a high negative predictive value (npv) in patients with known or suspected coronary artery disease (cad) similar to a normal gated myocardial perfusion imaging (gmpi). aim of this study was to evaluate npv of functional capacity during treadmill exercise in patients with normal gmpi in pakistani population. methods: this was a prospective study which ...