BACKGROUND Glucocorticoid receptor gene polymorphism (NR3C1 646 C>G) may play an important role in the development of severe bronchial asthma and resistance to glucocorticoids (GCs). OBJECTIVE The aim of the present study was to determine the relation between the 646 C>G polymorphism of the glucocorticoid receptor gene (NR3C1) and resistance to GCs with development of severe bronchial asthma....

We compare nuclear globular clusters (nGCs) in dwarf galaxies and Galactic GCs with extended (hot) horizontal branches (EHBs-GCs) in order to test the suggested external origin of the latter and the conditions at which GC self-enrichment can operate. Using luminosities and structural parameters of nGCs in low-mass (mainly late-type) dwarf galaxies from HST/ACS imaging we derive the present-day ...

Young neurons born in the subventricular zone (SVZ) of adult mice migrate to the olfactory bulb (OB) where they differentiate into granule cells (GCs) and periglomerular interneurons. Using retroviral labeling of precursors in the SVZ, we describe five stages and the timing for the maturation of newly formed GCs: (1) tangentially migrating neuroblasts (days 2-7); (2) radially migrating young ne...

Context. In recent years, increasing evidence for chemical complexity and multiple stellar populations in massive globular clusters (GCs) has emerged, including extreme horizontal branches (EHBs) and UV excess. Aims. Our goal is to improve our understanding of UV excess in compact stellar systems, covering the regime of both ultra-compact dwarf galaxies (UCDs) and massive GCs. Methods. We use d...

Root-knot nematodes (RKNs; Meloidogyne spp.) induce feeding cells (giant cells; GCs) inside a pseudo-organ (gall) from still unknown root cells. Understanding GCs ontogeny is essential to the basic knowledge of RKN-plant interaction and to discover novel and effective control strategies. Hence, we report for the first time in a model plant, Arabidopsis, molecular, and cellular features concerni...

Extensive studies during the past decades provided compelling evidence that glucocorticoids (GCs) have the potential to affect the development, survival and death of neurones. These observations, however, reflect paradoxical features of GCs, as they may be critically involved in both neurodegenerative and neuroprotective processes. Hence, we first address different aspects of the complex role o...

This paper supplements Jiang et al. (2003), who studied 172 M31 globular clusters (GCs) and globular cluster candidates from Battistini et al. (1987) on the basis of integrated photometric measurements in the BeijingArizona-Taiwan-Connecticut (BATC) photometric system. Here, we present multicolor photometric CCD data (in the BATC system) for the remaining 39 M31 GCs and candidates. In addition,...

Background and Objectives:Histochemical studies have shown that differentiated gastric cancer(D-GC)can be classified according to the phenotype of expressed mucin.In the present study, we investigated the biological divergence of early stage D-GCs expressing different types of mucin. Methods:Specimens from 73 surgically resected early stage D-GCs were classified on the basis of the phenotype of...

Objective of this study was to examine the effect of sodium nitroprusside (SNP), a nitric oxide (NO) donor on steroid synthesis, growth and apoptosis of buffalo granulosa cells (GCs) in vitro. Follicular fluid of antral follicles (3-5 mm diameter) was aspirated and GCs were cultured in 0 (control), 10, 10, 10, 10 M of SNP for 48 h. To evaluate whether this effect was reversible, GCs were cultur...

Polycystic ovarian syndrome (PCOS) is associated with anovulatory infertility. Luteinizing hormone/chorionic gonadotropin receptor (LHCGR), which is critical for ovulation, has been suggested to be expressed prematurely in the ovarian follicles of women with PCOS. The objective of this study was to analyse the expression and activity of LHCGR in ovarian granulosa cells from PCOS patients and th...