BACKGROUND Risk models of chemotherapy-induced (CIN) and febrile neutropenia (FN) have to date focused on determinants measured at the start of chemotherapy. We extended this static approach with a dynamic approach of CIN/FN risk modeling at the start of each cycle. DESIGN We applied predictive modeling using multivariate logistic regression to identify determinants of CIN/FN episodes and rel...

RUNX1, a master transcription factor of hematopoiesis, was shown to orchestrate both cell proliferation and differentiation during granulopoiesis by regulating microRNAs (miRs). In this study, taking advantage of the miR-ON reporter system, we monitored first, how the granulocyte colony stimulation factor (GCSF) temporally modulates the concomitant level variation of miR-221 and one of its prot...

Granulocyte colony-stimulating factor (GCSF) and its receptor (GCSFR), also known as CSF3 and CSF3R, are required to maintain normal neutrophil numbers during basal and emergency granulopoiesis in humans, mice and zebrafish. Previous studies identified two zebrafish CSF3 ligands and a single CSF3 receptor. Transient antisense morpholino oligonucleotide knockdown of both these ligands and recept...

Cardiovascular disease remains the main cause of morbidity and mortality in maintenance haemodialysis patients. This study was designed to evaluate granulocyte colony stimulating factor (G-CSF) level in chronic renal failure patients, and to clarify its impact on neutrophil activation, endothelial dysfunction and haemostatic activation in these patients. Thirty patients on regular haemodialysis...

Agranulocytosis is a rare condition with a reported incidence ranging from one to five cases per million population per year. Most commonly, agranulocytosis is secondary to chemotherapeutic agents, however, other medications have also been associated with it. An immune mediated destruction of circulating granulocytes and/or granulocyte precursors secondary to drug-dependent or drug-induced anti...

Both chronic and binge alcohol abuse can be significant risk factors for inflammatory lung diseases such as acute respiratory distress syndrome and chronic obstructive pulmonary disease. However, metabolic basis of alcohol-related lung disease is not well defined, and may include key metabolites of ethanol [EtOH] in addition to EtOH itself. Therefore, we investigated the effects of EtOH, acetal...

As more and more life science researchers start to take advantages of grid technologies in their work, the demand increases for a robust yet easy to use metascheduler or resource broker. In this paper, we have extended the metascheduler CSF4 by providing a Virtual Job Model (VJM) to synchronize the resource co-allocation for cross-domain parallel jobs. The VJM eliminates dead-locks and improves...

Granulocyte colony-stimulating factor (G-CSF) and stem cell factor (SCF) have been shown t o stimulate the circulation of hematopoietic progenitor cells in both mice and nonhuman primates. We evaluated the immunophenotype and cell cycle status of CD34+ cells isolated from the bone marrow (BM) and leukapheresis product of cytokine-mobilized nonhuman primates. CD34+ cells were isolated from rhesu...

Since December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged and spread quickly worldwide. The disease is generally mild in adult people but any with comorbidities may proceed to distress (ARDS), pneumonia, multi-organ dysfunction. By performing molecular tests on secretions can diagnose virus. Elevated C-reactive protein (CRP) normal/low white cell counts a...