Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and is divided into two major histological subgroups, i.e., embryonal (ERMS) and alveolar RMS (ARMS). RMS can show HEDGEHOG/SMOOTHENED (HH/SMO) signaling activity and several clinical trials using HH inhibitors for therapy of RMS have been launched. We here compared the antitumoral effects of the SMO inhibitors GDC-0449, ...

PURPOSE The hedgehog (Hh) signaling pathway, a key regulator of cell growth and differentiation during development is implicated in pathogenesis of certain cancers. Vismodegib (GDC-0449) is a small-molecule inhibitor of smoothened, a key component of Hh signaling. This phase I trial assessed GDC-0449 treatment in patients with solid tumors refractory to current therapies or for which no standar...

BACKGROUND AND PURPOSE Acceleration of intra-aneurysmal clot organization and fibrosis may be a solution to preventing aneurysm recanalization after endovascular treatment. The purpose of this study was to evaluate the short-term efficacy and long-term safety of the new Matrix coil system. METHODS Matrix coils consist of thin platinum coils covered with a bioabsorbable, polymeric material (po...

BACKGROUND AND PURPOSE The purpose of this study was to document the incidence and radiologic appearance of thromboembolic events during Guglielmi detachable coil (GDC) embolization for asymptomatic basilar artery (BA) bifurcation and BA-superior cerebellar artery (SCA) aneurysms by using diffusion-weighted (DW) MR imaging, with special emphasis on the evidence of thromboembolic events in vascu...

Existing Global Data Computation (GDC) protocols for asynchronous systems are designed for fully connected networks. In this paper, we discuss GDC in a dedicated asynchronous chordal ring, a type of un-fully connected networks. The virtual links approach, which constructs t+1 (t<n) process-disjoint paths for each pair of processes without direct connection to tolerate failures (where t is the m...

The generalized dominance computation (GDC) problem is stated as follows: Let A = fa 1 ; a 2 ; : : :; a n g be a set of triplets, i.e. a i = (x i ; y i ; f i), \<" be a linear order relation deened on x-components, \<" be a linear order relation deened on y-components and \" an abelian operator deened on f-components. It is required to compute for every a i 2 A, the expression D(a i) = f j 1 f ...

Combinations of MAP/ERK kinase (MEK) and phosphoinositide 3-kinase (PI3K) inhibitors have shown promise in preclinical cancer models, leading to the initiation of clinical trials cotargeting these two key cancer signaling pathways. GDC-0973, a novel selective MEK inhibitor, and GDC-0941, a class I PI3K inhibitor, are in early stage clinical trials as both single agents and in combination. The d...

Spontaneous rupture of cerebral aneurysms typically results in subarachnoid hemorrhage. The primary goal of treatment of cerebral aneurysms is to prevent future rupture. Surgical clipping had been the mainstay of treatment of both ruptured and unruptured cerebral aneurysms. In 1991, Guglielmi detachable coil (GDC) embolization was introduced as an alternative method for treating selected patien...

High power density operation is essential for cost reduction in solid oxide fuel cells (SOFCs), and thus the present work proposes a highly active Gd0.5Sr0.5CoO3−δ (GSC) Ce0.8Gd0.2O1.9 (GDC) nanocomposite cathode intermediate-temperature SOFCs. Its structure formed by using GSC-GDC particles synthesized via spray pyrolysis, which produces uniform-sized secondary consisting of nano-sized GSC GDC...