Abstract Autophagy contributes to the selective degradation of liquid droplets, including P-Granule, Ape1-complex and p62/SQSTM1-body, although molecular mechanisms physiological relevance remain unclear. In this report, we describe properties endogenous p62-bodies, effect autophagosome biogenesis on these bodies, in vivo significance their turnover. p62-bodies are low-liquidity gels containing...