نتایج جستجو برای: gemistocytic glioblastomas
تعداد نتایج: 2385 فیلتر نتایج به سال:
BACKGROUND Glioblastomas are the most frequent type of malignant primary brain tumor with a median overall survival less than 15 months. Therapy resistance of glioblastomas has been attributed to the presence of tumor initiating stem-like cells (TSCs). TSC-related markers have therefore been suggested to have promising potentials as prognostic markers in gliomas. METHODOLOGY/PRINCIPAL FINDING...
AIMS The initial aims were to use recently available observations of glioblastomas (as part of a previous study) that had been imaged twice without intervening treatment before receiving radiotherapy in order to obtain quantitative measures of glioma growth and invasion according to a new bio-mathematical model. The results were so interesting as to raise the question whether the degree of radi...
Brain tumours kill more children and adults under 40 than any other cancer, with approximately half of primary brain being diagnosed as high-grade malignancies known glioblastomas. Despite de-bulking surgery combined chemo-/radiotherapy regimens, the mean survival for these patients is only around 15 months, less 10% surviving over 5 years. This dismal prognosis highlights urgent need to develo...
While allelic losses and mutations of tumor suppressor genes implicated in the etiology of astrocytoma have been widely assessed, the role of epigenetics is still a matter of study. We analyzed the frequency of promoter hypermethylation by methylation-specific PCR (MSP) in five tumor suppressor genes (PTEN, MGMT, RASSF1A, p14(ARF), and p16(INK4A)), in astrocytoma samples and cell lines. RASSF1A...
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