A simple cell model consisting of a gene regulatory network with epigenetic feedback regulation is studied to evaluate the effect of epigenetic dynamics on adaptation and evolution. We find that, the type of epigenetic dynamics considered enables a cell to adapt to unfamiliar environmental changes, for which no regulatory program has been prepared, through noise-driven selection of a cellular s...

aim : evaluation of biological characteristics of 13 identified proteins of patients with cirrhotic liver disease is the main aim of this research.   background : in clinical usage, liver biopsy remains the gold standard for diagnosis of hepatic fibrosis. evaluation and confirmation of liver fibrosis stages and severity of chronic diseases require a precise and noninvasive biomarkers. since the...

Abstract In this study, we performed RNA sequencing of Prx II +/+ and ?/? dermal mesenchymal stem cells (DMSCs) to identify differentially expressed genes (DEGs). To explore the role in DMSCs, Gene Ontology analysis DEGs. The results showed that DEGs were mainly involved biological processes cell migration, intercellular adhesion, coordination regulation homing. Through construction protein–pro...