In the United States, few Food and Drug Administration (FDA)-approved options exist for the treatment of focal cartilage and osteochondral lesions. Developers of products for cartilage repair face many challenges to obtain marketing approval from the FDA. The objective of this review is to discuss the necessary steps for FDA application and approval for a new cartilage repair product. FDA Guida...

Modeling of imperfect repair through perfect renewal process uses an ‘‘as good as new’’ repair assumption and nonhomogeneous Poisson process uses an ‘‘ABAO’’ repair assumption. In practice, repair actions do not result in such extreme situations but in a complex transitional one, that is, general repair. This article discusses generalized renewal process for an aero engine as repairable compone...

Inguinal hernia repair has been a common procedure performed by general surgeons. Recently, a newly developed approach has been introduced using the pre-peritoneal laparoscopic repair. The laparoscopic approach allows patients to recover faster, with less pain, however, a disadvantage is the higher cost. We conducted a retrospective study of inguinal hernia repairs performed by one surgeon at t...

although the increase in the number of core sutures during flexor tendon repair increases the tensile strength of the repair, both increased handling at the time of repair and increased bulk at the repair site have been hypothesized as affecting clinical outcomes by increasing gliding resistance. the purpose of our study was to assess whether increasing the number of core sutures from two stran...

purpose: to investigate the risk factors of wound dehiscence and lens extrusion following blunt trauma in patients with penetrating keratoplasty (pk) as well as the results of treatment. methods: in a retrospective case series, 7 eyes of 7 patients including 6 male and one female subjects were investigated. all cases received primary care at the time of referral and then underwent secondary rep...

Abstract: The present investigation deals with M/G/1 retrial queue with unreliable server and general retrial times. The server is subject to breakdowns and takes some setup time before starting the repair. The server renders first essential phase of service (FES) to all the arriving customers whereas second optional phase services (SOS) are provided after FES to only those customers who opt fo...

Purpose. To evaluate the feasibility, safety, and effectiveness of laparoscopic transabdominal preperitoneal (TAPP) inguinal hernia repair using a memory-ring patch (Polysoft™ mesh). Patients and Methods. Between April 2010 and March 2013, a total of 76 inguinal hernias underwent TAPP repair using Polysoft mesh in 67 adults under general anesthesia. Three different senior resident surgeons perf...

Inguinal hernia repair is one of the most common procedures in general surgery. All anesthetic methods can be used in inguinal hernia repairs. Local anesthesia for groin hernia repair had been introduced at the very beginning of the last century, and gained popularity following the success reports from the Shouldice Hospital, and the Lichtenstein Hernia Institute. Today, local anesthesia is rou...