The Mantel-Haenszel procedure for comparing sets of time-to-response data is adaptable to data that can be stratified on other variables. A particular adaptation, which we have used, is one in which animals from the same litter have been assigned to different treatment groups, e.g., some to a control group and some to a drug treatment group. The time to response used was that of tumor appearanc...

This article presents a meta-analysis of studies investigating the effectiveness of the Mantel-Haenszel (MH) procedure when used to detect differential item functioning (DIF). Studies were located electronically in the main databases, representing the codification of 3,774 different simulation conditions, 1,865 related to Type I error and 1,909 to statistical power. The homogeneity of effect-si...

BACKGROUND There are contradictory reports on the relationship between acne vulgaris and cigarette smoking. The objective of this study was to examine the relation between acne and cigarette smoking in a case-control study. METHODS A questionnaire on smoking habits was offered to 350 patients with acne vulgaris and 350 patients suffering from skin diseases other than acne, aged 15-40 years, a...

OBJECTIVE To conduct a systematic review on the safety of ranibizumab injections for diabetic macular edema by meta-analysis of recently conducted level 1 randomized clinical trials. DESIGN A meta-analysis and systematic review. METHODS Main outcome measures of permissible studies were extracted and reported. The relative risk (RR) for thromboembolic events (TEEs) was calculated for those s...

The coin package implements a unified approach for conditional inference procedures commonly known as permutation tests. The theoretical basis of design and implementation is the unified framework for permutation tests given by Strasser and Weber (1999). For a very flexible formulation of multivariate linear statistics, Strasser and Weber (1999) derived the conditional expectation and covarianc...

The objective of this study was to evaluate the behavioral risks that are associated with human herpesvirus 8 (HHV-8) infection in a cohort of young homosexual men. Seventy-nine subjects (ages 22-33 years) who completed a questionnaire about their sexual and drug use behavior over the preceding year were recruited from the San Francisco Young Men's Health Study. Plasma samples were tested for a...

BACKGROUND Although minimal intervention dentistry (MID) is on the increase, little is known about the patterns of knowledge, attitudes, and behaviors of dentists in the United States. METHODS Federal service and civilian dentists who were active members of the American Dental Association (N = 1,500) received a pretested questionnaire about their knowledge, attitudes, and behaviors concerning...

Objectives: To assess the 2008–2012 Canadian contribution to the Otolaryngology literature. Methods: All articles published from January 2008 December 2012 in 5 Otolaryngology journals were reviewed. Nationality, number of authors, and study type were extracted. The output, number of authors, and study type of Canadian papers were compared to International papers using Mantel-Haenszel Common Od...

Background: Antiseptic scrub and paint can reduce bacterial colonization and postoperative wound infection. Two forms of antiseptics, povidone iodine and chlorhexidine, are commonly used in the operating theater. Objective: To study the efficacy of the reduction of bacterial colonization and surgical wound infection among these antiseptic. Material and Method: Five hundred surgical patients wer...

BACKGROUND Several randomized controlled trials (RCT) have reported no difference in long-term mortality between coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI). The purpose of this pooled observational analysis was to compare recent retrospective studies examining long-term survival of patients with multi-vessel coronary artery disease undergoing CABG and PC...