Obesity is a chronic, complex, and heterogeneous disease that affected by genetic, developmental, biological, environmental factors; thus, it necessary to approach obesity with an integrated comprehensive treatment strategy. Because difficult achieve maintain successful long-term weight loss through lifestyle modifications in most obese patients, pharmacological the of should be considered as a...

Colistin is highly promising against multidrug-resistant and extensively drug-resistant bacteria clinically. Bacteria are resistant to colistin mainly through mcr chromosome-mediated lipopolysaccharide (LPS) synthesis-related locus variation. However, the current understanding cannot fully explain resistance mechanism in -negative colistin-resistant strains. Significantly, contribution of efflu...

background: recent researches have led to find strategies to prevent relapse and to improve survival for gastric cancer patients, including preoperative neo-adjuvant approaches. however, the efficacy of some neo-adjuvant regimens including 5-fluorouracil, cisplatin, and docetaxel have been less investigated. the present study evaluated the outcome and mid-term survival of patients with gastric ...

Abstract Purpose of Review Young women who carry a genetic predisposition to breast cancer need balance surgical and nonsurgical risk reducing options with childbearing. In this review, we explore how make decisions without the benefit official guidelines in context frequently contradictory strategies. Recent Findings Women reproductive age known BRCA mutations receive incomplete conflicting ad...

The treatment of breast cancer has progressed substantially over the past 15 years. Data from randomized adjuvant trials have shown that the risk of disease recurrence and death is significantly reduced when adjuvant chemotherapy and/or hormonal therapy is added to treatment. As new strategies are incorporated, one of the continued controversies in patient management is whether adjuvant anthrac...