CP# 02.01.08 Familial polyposis gene testing CP# 02.01.14 Gene expression profile testing for breast cancer CP# 11.04.02 Genetic testing for autism spectrum disorders CP# 02.01.02 Genetic testing for breast and ovarian cancer CP# 02.01.07 Genetic testing for cystic fibrosis CP# 05.01.03 Genetic testing for G1691A polymorphisms Factor V Leiden CP# 04.01.02 Genetic testing for Long QT syndrome (L...

pancreatic cancer (pc) is a progressive, fatal disease with a high degree of malignancy. more than 40000 peoplediefrom this cancer annually in the united states. as a multifactorial condition, pc has a complex nature, and there are several genes and signalingpathwaysimplicated in pc pathogenesis and progression. there are diffèrent mutations in master genesincludingtumorsuppressors and oncogene...

perrault's syndrome (p.s.) is rare. the combination of gonadal dysgenesis and hearing loss was accompanied by 46,xxkaryotype in three sisters with parental consanguineous marriage. genetic investigation revealed normal female karyotype, positive liarr and negative fluorescence ipj-bodies, which was confirmed by molecular study on the basis of fluorescence in situ hybridization (pish), with appl...

gold preparations are one of the oldest disease modifying drugs in the treatment of rheumatoid arthritis. this are different reports about the effects and complications of these compoumis. these opposite reports may he due to the difference in genetic ami ethnic background of patients. this study was designed to evaluate our results in gold therapy ami compare them with those of western countri...

dadresanfar b 1 ehsani m 2 vallaee n 3 khalilak z #1   1- assistant professor, endodontic dept, islamic azad university, dental branch, tehran, iran   2-dentist   3- faculty member of islamic azad university, dental branch   corresponding author: khalilak z: endodontic dept, no 4 , 10th neyestan ave, pasdaran. tehran iran   tel: 0 21 22564571-3 email: dr.z.khalilak@ gmail.com  background and ai...

background: ionizing radiation irradiated from iodine-131 can induce dna damage and cell death. the cellular dna damage is the cause of mutation and cancer. the micronucleus assay in polychromatic erythrocytes was applied to assess the radio-protective effect of turmeric extract on genotoxic potential of iodine therapy. materials and methods: thirty six male albino rats were randomly divided in...

I n the 1990s, gene therapy emerged as a novel strategy for treatment of human diseases. Early attempts at gene therapy in the United States centered on treatment of severe combined immunodeficiency due to adenosine deaminase deficiency, ornithine transcarbamylase deficiency, and hemophilia. Early setbacks gave way to later successes, resulting in increased acceptance of the concept of genetic ...

today multinational studies using genome-wide association scan (gwas) for >1000,000 polymorphisms on >100,000 cases with major psychiatric diseases versus controls, combined with next-generation sequencing have found ~100 genetic polymorphisms associated with schizophrenia (scz), bipolar disorder (bd), autism, attention deficit and hyperactivity disorder (adhd), etc. however, the effect size of...

Gene therapy is the process of treating a particular disease through the introduction of genetic material in order to elicit a therapeutic benefit [Stone, 2010]. The defective gene of a diagnosed patient can be corrected by a number of different strategies such as “gene replacement”, “gene correction”, and “gene augmentation” [Katare and Aeri, 2010]. In replacement therapy, a normal gene is ins...

The term “personalized medicine” appeared only 20 years ago, but individual approaches to the therapy were known for more than a hundred years. genome decoding and development of pharmacogenetics in recent decades have opened up new ways medicine understanding concept medicine”. article uses example nephrological diseases (Denis–Drash syndrome, Freiser hypophosphatemic rickets, nephrotic syndro...