نتایج جستجو برای: genetic vaccine
تعداد نتایج: 717612 فیلتر نتایج به سال:
Human immunodeficiency virus-1 (HIV-1) has a high degree of genetic and antigenic diversity that has impeded the development of an effective vaccine using traditional methods. We are attempting to develop an AIDS vaccine by employing strategies that include structural biology and computational modelling, in an effort to develop immunogens capable of eliciting neutralizing antibodies of the requ...
Influenza A(H1N1)pdm09 viruses predominated in the European influenza 2015/16 season. Most analysed viruses clustered in a new genetic subclade 6B.1, antigenically similar to the northern hemisphere vaccine component A/California/7/2009. The predominant influenza B lineage was Victoria compared with Yamagata in the previous season. It remains to be evaluated at the end of the season if these ch...
به کارگیری روشهای بهینه سازی در تحلیل سیستم های عمران، همانند شبکه های توزیع آب و جمع آوری فاضلاب، منابع آب، سازه و... در چند دهه اخیر مورد توجه متخصصین این رشته واقع شده است. با توجه به هزینه بری فراوان طرحهای آب و فاضلاب (شبکه های توزیع آب و جمع آوری فاضلاب) لزوم به کارگیری روشهای نو و به صرفه برای طراحی و اجرای سیستم های مذکور احساس می شود. روشهای سنتی و مرسوم طراحی شبکه های توزیع آب و جمع آ...
background: plasmodium vivax malaria accounts for approximately 88% of malaria cases in iran. there is limited information on genetic diversity of p. vivax in the country and a need to develop and apply an effective vaccine against the disease is necessary. among many potential candidates, msp -3β gene is promising target. this study was designed and carried out to determine the variation of...
UNLABELLED Standardized assessments of HIV-1 vaccine-elicited neutralizing antibody responses are complicated by the genetic and antigenic variability of the viral envelope glycoproteins (Envs). To address these issues, suitable reference strains are needed that are representative of the global epidemic. Several panels have been recommended previously, but no clear answers have been available o...
background: cervical cancer has been shown to be highly associated with human papillomavirus (hpv) infection. the viral oncogenes e6 and e7 are constantly expressed by the tumor cells and are therefore potent targets for therapeutic genetic vaccination. in the present study, it was investigated the potential effect of hpv-16 e6, e7 and l1 co-administration to activate specific cytotoxic t lymph...
A live attenuated porcine reproductive and respiratory syndrome (PRRS) vaccine virus has been shown to revert to virulence under field conditions. In order to identify genetic virulence determinants, ORF1 from the attenuated vaccine virus and three Danish vaccine-derived field isolates was sequenced and compared with the parental strain of the vaccine virus (VR2332). This revealed five mutation...
While there has been remarkable progress in understanding the biology of HIV-1 and its recognition by the human immune system, we have not yet developed an efficacious HIV-1 vaccine. Vaccine challenges include the genetic diversity and mutability of HIV-1 which create a plethora of constantly changing antigens, the structural features of the viral envelope glycoprotein that disguise conserved r...
Interrogating immune correlates of infection risk for efficacious and non-efficacious HIV-1 vaccine clinical trials have provided hypotheses regarding the mechanisms of induction of protective immunity to HIV-1. To date, there have been six HIV-1 vaccine efficacy trials (VAX003, Vaxgen, Inc., San Francisco, CA, USA), VAX004 (Vaxgen, Inc.), HIV-1 Vaccine Trials Network (HVTN) 502 (Step), HVTN 50...
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