Genome-wide evaluation uses the associations of a large number of single nucleotide polymorphism (SNP) markers across the whole genome and then combines the statistical methods with genomic data to predict the genetic values. Genomic predictions relieson linkage disequilibrium (LD) between genetic markers and quantitative trait loci (QTL) in a population. Methods that use all markers simultaneo...

The conversion of nucleotide sequences into digital genomic signals allows using signal processing methods for the analysis of genomic data. Nucleotide genomic signal (NGS) analysis reveals surprising regularities in the distribution of nucleotides and pairs of nucleotides, in both prokaryotes and eukaryotes. These structural and statistical restrictions of genomic sequences would be difficult ...

selective signatures in whole genome can help us to understand the mechanisms of selection and to identify the genomic regions that have been under natural or artificial selection during long years. the objective of this study was to identify the genomic regions that have been under artificial and natural selection in baluchi and zel sheep breeds. 143 sheep from baluchi (n=96) and zel breeds (n...

hymenolepis nana is a common parasite of rodents as well as human intestine. this parasite has beenreported from all over the world, including iran. the infection rate has been reported up to 40% in someareas. the infection has various clinical manifestations. the parasite could establish severe hyperinfection inpatients with immune deficiency. regarding the rodents as hosts of the parasite, th...

Most human diseases and agriculturally important traits are complex. Dissecting their genetic architecture requires continued development of innovative and powerful statistical methods. Corresponding advances in computing tools are critical to efficiently use these statistical innovations and to enhance and accelerate biomedical and agricultural research and applications. The genome association...

Identifying the genomic regions that underlie complex phenotypic variation is a key challenge in modern biology. Many approaches to quantitative trait locus mapping in animal and plant species suffer from limited power and genomic resolution. Here, I investigate whether bulk segregant analysis (BSA), which has been successfully applied for yeast, may have utility in the genomic era for trait ma...

The estimation of ancestral and current effective population sizes in expanding populations is a fundamental problem in population genetics. Recently it has become possible to scan entire genomes of several individuals within a population. These genomic data sets can be used to estimate basic population parameters such as the effective population size and population growth rate. Full-data-likel...

MOTIVATION The identification of interactions between drugs and target proteins is a key area in genomic drug discovery. Therefore, there is a strong incentive to develop new methods capable of detecting these potential drug-target interactions efficiently. RESULTS In this article, we characterize four classes of drug-target interaction networks in humans involving enzymes, ion channels, G-pr...