OBJECTIVE To evaluate the safety and efficacy of two intralesional doses of recombinant human interferon-beta (r-hIFN-beta: Rebif, Ares Serono), given 3 times a week for 3 weeks, in the treatment of condyloma acuminatum. DESIGN A randomised, double-blind, within-patient, placebo-controlled study. SUBJECTS 25 patients (24 males, 1 female) with a history of condyloma acuminatum. Twenty had fa...

Toll-like receptors (TLRs) are expressed in immune and tumor cells and recognize pathogen-associated molecular patterns. Cervical cancer (CC) is directly linked to a persistent infection with high risk human papillomaviruses (HR-HPVs) and could be associated with alteration of TLRs expression. TLR9 plays a key role in the recognition of DNA viruses and better understanding of this signaling pat...

Carcinoma cuniculatum (CC) is a rare variant of verruci-form squamous cell carcinoma (SCC) without metastatic potential. Curative treatment usually requires large surgical resection. We describe here a case of perineal CC complicating giant condyloma in an HIV-infected patient treated with combined systemic isotretinoin and interfe-ron therapy when surgery, radiotherapy or chemotherapy could no...

We report the case of 3-year-old girl with condyloma acuminatum. She was brought to our clinic with pruritus, painful urination and four discharge and treated with electrocautery. Histological examination revealed acanthosis, nuclear basophilic inclusions and vacuolar degeneration. In this case, transmission of the human papilloma virus might have occurred during close, non-sexual contact with ...

Number of lesions Single: 29 patients Single: 3 patients Duration of lesions 1 month to 7 years (6 patients more than 1 year) 1 month to 2 years (5 patients more than 1 year) Risky sexual practices 28 patients (partner with condyloma, 7 cases) 5 patients (partner with condyloma, 1 case) Associated STD HIV status in 1 patient Gonococcal urethritis, 1 patient Latent syphilis, 1 patient Active hep...

To our knowledge, this is the first study that focuses on risk factor of urethral condyloma (UC). The subjects of our study included genital warts patients who had been diagnosed as having condyloma acuminatum of penile skin (CAPS) with/without UC. Relationship with UC of number of life time female partners, co-infection with urethritis, circumcision status, number of CAPS and wart diameter wer...