An analytical method based on isocratic reverse phase high-performance liquid chromatography was developed and validated for the separation and quantification of eight antidiabetic drugs: rosiglitazone, pioglitazone, glipizide, gliclazide, repaglinide, nateglinide, glibenclamide, and glimepiride for their application in human plasma assay. Metformin is used as internal standard. Analysis was do...

A rapid, sensitive, accurate and specific HPLC assay with UV-Visible detection (253nm) for the determination of glibenclamide in rat serum was developed and validated. Glipizide was used as an internal standard (IS). The serum proteins were precipitated by a single step liquid-liquid extraction using methanol. Chromatographic separation was achieved with a combination of acetonitrile and 25mM m...

The present investigation was aimed to formulate and evaluate the gastro-retentive floating microballoons of glipizide using hydrophilic polymers hydroxypropyl methylcellulose (HPMC) and Eudragit RS100 (RS 100) by emulsion solvent evaporation technique. The floating microballoons were evaluated using micromeritic properties, buoyancy, in vitro drug release, scanning electron microscopy and stab...

This retrospective study assessed the prevalence of moderate to severe chronic kidney disease (CKD) among nursing home (NH) residents with type 2 diabetes. The pattern of oral antidiabetic drug (OAD) use and their concordance with the National Kidney Foundation (NKF) guideline and prescribing information (PI) was also assessed. About half (47%) of diabetic residents had moderate to severe CKD. ...

1. Srinivasan et al., (2005) developed a new rat model that replicates the natural history and metabolic characteristics of human type 2 diabetes and is also suitable for pharmacological screening. They used the high-fat diet and streptozotocin as diabetic inducers. They also studied the effect of two different combinations such as normal pellet diet + STZ and high fat diet + STZ and found that...

The aim of this study was to investigate the influence of pH, buffer species and ionic strength on the release mechanism of Glipizide (G) from matrix tablets containing chitosan and xanthan gum prepared by a hot-melt extrusion process. The release mechanisms were controlled by the solubility and ionic properties of the polymers. All directly compressed (DC) tablets prepared in this study also e...

Department of Pharmaceutical Technology, Meerut Institute of Engineering & Technology, NH-58, Baghpat Road-Bypass Crossing, Meerut-250005 (U.P), India ABSTRACT Drug release from mucoadhesive patches at predetermined rate in oral cavity having distinct advantages over traditional dosage forms as tablets, gels and solutions. This review provides brief information about method of preparation and e...

A 60-year-old African-American man presented to the emergency department with malaise, fever, and mild shortness of breath. Following initial evaluation and application of supplemental oxygen, the patient was admitted to a step-down unit. Seventytwo hours following admission, his respiratory status declined, and he was transferred to the medical ICU. Following this transfer, endotracheal intuba...