Inhibiting the unfolded protein response (UPR) can be a therapeutic approach, especially for targeting the tumor microenvironment. Here, we show that compound C (also known as dorsomorphin), a small-molecule inhibitor of AMP-activated protein kinase (AMPK) and bone morphogenetic protein (BMP) signaling, inhibit the UPR-induced transcription program depending on the glucose deprivation condition...

The thioredoxin system, composed of thioredoxin (Trx) and thioredoxin reductase (TrxR), emerges as one of the most important thiol-based systems involved in the maintenance of the cellular redox balance. Thioredoxin-like-1 (TXL-1) is a highly conserved protein comprising an N-terminal Trx domain and a C-terminal domain of unknown function. Here we show that TXL-1 is a substrate for the cytosoli...

In this study, the effect of short-terms starvation (0, 2, 4 and 8 days) on plasma cortisol, glucose, triglyceride and cholesterol levels and also hepatosomatic index in Siberian sturgeon, Acipenser baerii, was investigated. After acclimation to experimental conditions for 10 days using formulated diet, 180 juvenile Siberian sturgeons (mean weight ? S.E.=19.3?0.4, n=15) were randomly distribute...

Title: Exploring the neuroprotective mechanism of poly-ICLC preconditioning against oxygen-glucose deprivation in the in vitro blood-brain barrier model. Abstract Approved:

Tribbles 3 (TRB3) is a recently recognized atypical inactive kinase that negatively regulates Akt activity in hepatocytes, resulting in insulin resistance. Recent reports link TRB3 to nutrient sensing and regulation of cell survival under stressful conditions. We studied the regulation of TRB3 by glucose, insulin, dexamethasone (Dex), and the unfolded protein response (UPR) in 3T3-L1 adipocytes...

(Molecular Cell 38, 487–499; May 28, 2010) We, the editors of Molecular Cell, were contacted by a concerned reader who informed us about duplicated image that appears in Figure 2A and S1E above paper. These images are pictures untreated control TSC2-/- p53-/- mouse embryonic fibroblasts. The authors no longer have access to original data published 11 years ago, but they believe these likely cam...

OBJECTIVE AMP-activated protein kinase (AMPK) and the ATP-sensitive K(+) (K(ATP)) channel are metabolic sensors that become activated during metabolic stress. AMPK is an important regulator of metabolism, whereas the K(ATP) channel is a regulator of cellular excitability. Cross talk between these systems is poorly understood. RESEARCH DESIGN AND METHODS Rat pancreatic beta-cells or INS-1 cell...

Oncogenes influence nutrient metabolism and nutrient dependence. The oncogene c-Myc stimulates glutamine metabolism and renders cells dependent on glutamine to sustain viability ("glutamine addiction"), suggesting that treatments targeting glutamine metabolism might selectively kill c-Myc-transformed tumor cells. However, many current or proposed cancer therapies interfere with the metabolism o...