نتایج جستجو برای: glutathione gsh
تعداد نتایج: 43024 فیلتر نتایج به سال:
Ifosfamide a clinically potent chemotherapeutic agent causes depletion of intracellular glutathione (GSH) levels in different cell types. GSH is the major intracellular reductant against oxidative stress. 4-hydroxyifosfamide (4-OH-IF), the activated form of ifosfamide, depletes GSH levels in T cells and NK cells which is accompanied by a decrease in T cell and NK function. Here we demonstrate f...
OBJECTIVES The influences of Pueraria candollei var. mirifica (PM), a Thai medicinal plant with long tradition of medicinal consumption among menopausal women for rejuvenation and estrogen hormone replacement, on oxidative status in ovariectomized (OVX) mice were determined. METHODS The crude extract of PM and its active phytoestrogen, miroestrol (MR), were given to OVX mice. The effect of th...
The effect of haloperidol administration on lipid peroxidation and glutathione/protein thiol homeostasis in the brain was examined 4 h following subcutaneous administration of a single dose of haloperidol; 1.0, 1.5, 2.0 or 2.5 mg/kg b.wt. Glutathione (GSH) levels decreased significantly in cortex, striatum and midbrain after haloperidol administration. Maximal decrease of GSH was observed in th...
The dominant onion bulb glutathione S-transferases (GSTs) (named as GSTc, GSTd and GSTe) were separated by DEAE cellulose column chromatography, and the inhibitory interactions of glutathione (GSH) derivatives (S-methyl GSH, S-propyl GSH, S-butyl GSH, and S-hexyl GSH), four coumarins (coumarin, 7-hydroxy coumarin, esculetin and scopoletin) were tested with theses GSTs. The activities of GSTs we...
The prevalence of asthma has increased worldwide. The reasons for this rise remain unclear. Oxidative stress plays an important role in the pathogenesis of asthma. Glutathione (GSH) is the major representative of the class of nonprotein thiols and plays a pivotal role in a variety of enzymatic and nonenzymatic reactions that protect tissues against oxidative stress. In antioxidative reactions, ...
Glutathione (GSH) is one of the most important antioxidants that plays an essential role in detoxification of reactive oxygen species (ROS) which oxidizes to glutathione disulfide (GSSG). Paraquat (PQ), awidely used herbicide, causes pulmonary injury with the productionof ROS. Excessive ROS accumulation as a consequence of PQ exposure are frequently targeted by GSH thereby oxidative stress lead...
Effect of superanutritional levels of selenium (Se) as sodium selenite (0.5 and 1.5 ppm) given orally to Balb/c mice for one and two weeks was observed on the rate of DNA/RNA synthesis, levels of reduced as well as oxidized glutathione (GSH and GSSG) and glutathione peroxidase (GSH-Px)/glutathione-S-transferase (GSH-S-transferase) activities in spleen. Similar effect of three different concentr...
Recent evidence suggests that the endogenous antioxidant glutathione may play a protective role in cardiovascular disease. To directly investigate the role of glutathione in the regulation of glucose metabolism in hypertension, we studied the acute effects of in vivo infusions of this antioxidant (alone or in combination with insulin) on whole body glucose disposal (WBGD) using euglycemic gluco...
In Arabidopsis thaliana, biosynthesis of the essential thiol antioxidant, glutathione (GSH), is plastid-regulated, but many GSH functions, including heavy metal detoxification and plant defense activation, depend on cytosolic GSH. This finding suggests that plastid and cytosol thiol pools are closely integrated and we show that in Arabidopsis this integration requires a family of three plastid ...
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