Antibiotic resistance of pathogenic strains microorganisms is one the most difficultproblems modern medicine. An effective way to solve it synthesis new classesof antibacterial and antifungal drugs with a wide spectrum antiseptic action.Purpose research – types glycolic acid acylhydrazones(quinolin-8-yl)and investigation their antimicrobe activity.Material methods. The analysis activity wascarr...

Herein we report the fabrication of engineered poly(lactic acid-co-glycolic acid) nanoparticles via the PRINT (particle replication in nonwetting templates) process with high and efficient loadings of docetaxel, up to 40% (w/w) with encapsulation efficiencies >90%. The PRINT process enables independent control of particle properties leading to a higher degree of tailorability than traditional m...

Several polymers were used to delivery genes to diabetic animals. Polyaminobutyl glycolic acid was utilized to deliver IL-10 plasmid DNA to prevent autoimmune insulitis of non-obese diabetic (NOD) mouse. Polyethylene glycol grafted polylysine was combined with antisense glutamic acid decarboxylase (GAD) MRNA to represent GAD autoantigene expression. GLP1 and TSTA (SP-EX4) were delivered by bior...

Submit Manuscript | http://medcraveonline.com Abbreviations: PLGA: Poly Lactic-Co-Glycolic Acid; PEG: Polyethylene Glycol; FDA: Food and Drug Administration; AlgPLGANP: Alginate-PLGA Nanoparticle; PDI: Polydispersity Index; TRF: Tocotrienol Rich Fraction; FA: Folic Acid; α: Alpha; ZP: Zeta Potential; SEM: Scanning Electron Microscopy; PXRD: Powder X ray Diffraction; DSC: Differential Scanning C...

Polymers have been used since decades as carriers for chemotherapeutic drugs. Among the various controlled release polymer technologies PLGA [poly(lactic acid-co-glycolic acid)] has the greatest clinical impact till date. Precisely engineered PLGA’s is the need of the hour (Figure 1). For the first time, Elizabeth Enlow and colleagues have come out with a new strategy of fabricating PLGA via th...

An operationally simple protocol for the synthesis of 2,3-dihydrobenzo[f][1,4]oxazepin-3-ones, based on an Ugi reaction of an ortho-(benzyloxy)benzylamine, glycolic acid, an isocyanide and an aldehyde, followed by an intramolecular Mitsunobu substitution was developed. The required ortho-(benzyloxy)benzylamines have been in situ generated from the corresponding azides, in turn prepared in high ...

Ethylene glycol (EG) oxidation has been studied on Pt(111) and its vicinal surfaces in acidic media by cyclic voltammetry and infrared spectroscopy. Even at Pt(111) the C-C bond is readily broken and CO is formed at low potentials. Both types of steps catalyze the EG oxidation to CO2, being the {110} steps the most catalytic for the splitting of the C-C bond. Spectroscopic results show that gly...