Many studies have documented that during the development of left ventricular hypertrophy (LVH) coronary vascular growth lags behind that of cardiac muscle. To ascertain whether significant growth of coronary resistance vessels occurs with long-standing hypertension and LVH, we studied dogs with Goldblatt (one-kidney, one-clip) hypertension seven months after surgery. Left ventricular minimal co...

The following investigation was started on the assumption that the injection of renin in adequate amounts might have a greater effect in dogs with experimental renal "ischemia" of the Goldblatt type than in normal dogs, provided that endogenous renin were responsible for the experimental hypertension. Trained, unanesthetized dogs were used in order to eliminate the disturbing effects of anesthe...

1. Urinary kallikrein excretion was measured in rats by an enzyme kinetic method employing radioimmunoassay of generated bradykinin. 2. Rats given a sodium load (NaCl solution, 20 g/l, to drink) for 28 days showed acute and prolonged significant falls in urinary kallikrein excretion associated with suppression of plasma renin and angiotensin. 3. Conversely sodium-depleted rats showed increases ...

Atherosclerotic renovascular disease (ARVD) is a wellrecognized cause of arterial hypertension. However, the role of ARVD as an important contributor to renal failure remains a controversial issue. The original experiments of Goldblatt et al. [1] have demonstrated that arterial hypertension due to unilateral renal artery stenosis (RAS) can cause bilateral renal damages. Indeed, because of the r...

We studied postclamp renal artery pressure and renin release in eight conscious dogs with one-kidney Goldblatt hypertension. On normal sodium intake, intrarenal blockade of angiotensin II with Sar1-Ala8-angiotension II (P-113, saralasin acetate) markedly decreased postclamp renal artery pressure and increased renin release during the first 5 days after renal artery constriction. We found that 1...

The inotropic responsiveness to adrenergic stimulation is diminished in hypertension associated with left ventricular hypertrophy (LVH). This was shown in hypertrophied hearts from renal hypertensive rats (RHR) (two-kidney, one clip hypertension, Goldblatt) 6 weeks after renal artery clipping when compared to age-matched normotensive sham-operated controls (NR). The isoproterenol-stimulated ino...

Exchangeable sodium (NaE), plasma active renin concentration and blood pressure were measured in rats with a sole remaining kidney before and after the development of hypertension induced by clipping of the single renal artery and again after unclipping. Control observations were made in sham-clipped and sham-unclipped uninephrectomized rats. Renal artery clipping caused hypertension and expans...

INTRODUCTION Hypertension is one of the most frequently occurring diseases worldwide. Approximately 10% of the population with hypertension reveals the secondary type of the disease. The aim of the study was to evaluate the megakaryocyte-platelet system in the course of renovascular hypertension. MATERIAL/METHODS An experimental model of hypertension in rats according to Goldblatt was used in...