Gorham syndrome, which is also called diffuse lymphangiomatosis, is characterised by excessive osteolysis due to uncontrolled lymphatic or vascular proliferation involving bones, of unknown etiology. Chylothorax may accompany Gorham syndrome in case of invasion of lymphatic vessels, or thoracic duct due to neighboring affected ribs, scapula or vertebrae. Chylothorax and vertebral invasion is se...

Gorham disease is a rare condition characterized by intraosseous neoplastic proliferation of hemangiomatous tissue with progressive, massive osteolysis. We present a pathologically proved case of Gorham disease that involved the left parietal bone in a 23-year-old man. Imaging studies including conventional radiography of the skull, CT, MR imaging, and Technetium-99 m (Tc-99 m) scintigraphy dem...

Gotham's disease or vanishing bone is a rare disease with unknown etiology. Frequently, children and young adults are affected. It is characterized by proliferation of vascular or lymphatic tissue which results in destruction and resorption of bone. In this disease, the destructed bone is replaced either by hemangiomatous or lymphangiomatous tissue ( s) and in a later stage, fibrosis occurs. It...

An "Orthrius-group" of genera is proposed, and defined to include Aphelochroa Quedenfeldt, 1885; Caridopus Schenkling, 1908; Dozocolletus Chevrolat, 1842; Gyponyx Gorham, 1883; Languropilus Pic, 1940; Orthrius Gorham, 1876; Pieleus Pic, 1940; Xenorthrius Gorham, 1892; plus three new genera Neorthriusgen. n., Nonalatusgen. n. and Pseudoastigmusgen. n. A phylogeny of the 11 constituent Orthrius-g...

A 7-year-old girl with a history of headaches and Gorham disease was surgically treated in infancy for Chiari I malformation. Subsequent investigation revealed that her cerebellar tonsillar ectopia was due to a long-standing spinal CSF-lymphatic fistula causing intracranial hypotension. Percutaneous fistula closure was performed several times, resulting in transient symptomatic improvement.

Gorham syndrome is a rare disease that presents as progressive osteolysis, and may affect any part of the skeleton. The pathologic process involves the replacement of normal bone by aggressively expanding but non-neoplastic vascular tissue, resulting in massive osteolysis of the adjacent bone. If the spine and ribs are affected, the subsequent kyphosis and chest wall deformity may cause severe ...