BACKGROUND Brazil nuts provide a rich natural source of selenium, yet no studies have investigated the bioavailability of selenium in humans. OBJECTIVE We investigated the efficacy of Brazil nuts in increasing selenium status in comparison with selenomethionine. DESIGN A randomized controlled trial was conducted with 59 New Zealand adults. Participants consumed 2 Brazil nuts thought to prov...

BACKGROUND Selenium is a central determinant of antioxidative glutathione peroxidase 1 (GPx-1) expression and activity. The relevance of selenium supplementation on GPx-1 in coronary artery disease (CAD) needs to be established. We assessed the effect of selenium supplementation on GPx-1 in cell culture and on endothelial function in a prospective clinical trial. METHODS Human coronary artery...

Introduction: Nephrotoxicity as a side effect caused by the immunosuppressive drug, cyclosporine-A (CsA), can be a major problem in transplant medicine. Oxidative stress may play an important role in the CsA-induced nephrotoxicity. It has been shown that the antihypertensive drug, valsartan (Val), has also renoprotective effects but, its molecular mechanism is largely unknown. In the present st...

This study was conducted to investigate how the activity and expression of certain paramount antioxidant enzymes respond to grape seed extract (GSE) addition in primary muscle cells of goats. Gluteal primary muscle cells (PMCs) isolated from a 3-week old goat were cultivated as an unstressed cell model, or they were exposed to 100 µM H2O2 to establish a H2O2-stimulated cell model. The activitie...

Hepatic ischemia-reperfusion (I-R) injury causes acute organ damage or dysfunction, and remains a problem for liver transplantation. In the I-R phase, the generation of reactive oxygen species aggravates the injury. In the current study, a novel selenocysteine-containing 7‑mer peptide (H-Arg-Sec-Gly-Arg-Asn-Ala-Gln-OH) was constructed to imitate the active site of an antioxidant enzyme, glutath...

In this study, to reveal the antioxidant potential of goat milk cells, activities glucose-6-phosphate dehydrogenase (G6PD), glutathione peroxidase (GPx) and levels reduced nicotinamide adenine dinucleotide phosphate (NADPH), total (tGSH),malondialdehyde (MDA), vitamin C (Vit C) protein (TP) in cells were determined correlations between these parameters evaluated. Milk samples collected from 19 ...

Oxidative stress is common in several human and veterinary conditions it associated to alteration of the glutathione peroxidase (GPx) level. GPx an enzyme present erythrocytes, kidney, liver has a role protecting against oxidative damage. In this randomised double-blinded control trial on healthy dogs, we findings indicating that administration for total 35 days supplement containing S-acetyl-g...

Background: The aim of this study is to evaluate the effect 50 g oral glucose tolerance test (OGTT) on oxidative stress and interleukin-8 (IL-8) parameters in prediabetic pregnant women. Materials Methods: Fasting 1 hour blood samples were collected from 79 women who administered gr OGTT. Patients with a level 140–200 mg/dl considered as group. Thereafter, routine biochemical levels superoxide ...

introduction: electromagnetic fields (emfs) can influence the biological system by the formation of free radicals in cells. the emfs are able to deteriorate defense system against free radicals that leads to oxidative stress (os). lipid peroxidation process (lpo) is an index of oxidative stress, and the malandialdehyde (mda) is the final product of lpo. vitamin e is the most important antioxida...