نتایج جستجو برای: graft versus host disease

تعداد نتایج: 1951470  

Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment option for hematological disorders. Cyclosporine (CsA) is one of the major immunosuppressive agents for the prophylaxis against graft versus host disease (GvHD). In this retrospective study, we evaluated the effects of CsA serum levels on the incidence of acute GvHD and transplant outcomes. 103 adult patients rece...

Journal: :The Journal of clinical investigation 1971
R Storb R H Rudolph E D Thomas

Marrow grafts were carried out between 16 canine sibling donor-recipient pairs. The pairs were matched by serological histocompatibility testing and were nonreactive in a one-way mixed leukocyte culture. Recipients were prepared for transplantation by 1500-1580 R of total body irradiation. Donor marrow was infused within 4 hr of irradiation. Recipients were not given immunosuppressive drug ther...

2014
Clara Marino Espricigo Botari Adauto José Ferreira Nunes Mair Pedro de Souza Érica Sinara Lenharo Orti-Raduan Ana Gabriela Salvio

The graft-versus-host disease is the major cause of morbidity and mortality in patients who have undergone hematopoietic stem cell transplantation. Aiming at contributing to the understanding of the role of myeloid and plasmacytoid dendritic cells, and natural killer cells in chronic graft-versus-host disease, we examined biopsies of jugal mucosa of 26 patients with acute myeloid leukemia who h...

Journal: :Iranian journal of allergy, asthma, and immunology 2012
Ehteramolsadat Hosseini Anthony P Schwarer Mehran Ghasemzadeh

The non-classical MHC class-I mainly involves in the regulation of innate immune responses where HLA-E plays a significant role in the cell identification by natural killer cells. HLA-E is a main regulatory ligand for natural killer cells and given the importance of these effector cells in hematopoietic stem cell transplantation, we investigated the effect of HLA-E polymorphisms on post-hematop...

2011
Afonso Celso Vigorito Luis Fernando da Silva Bouzas Maria Cláudia Rodrigues Moreira Vaneuza Araújo Moreira Funke Virgílio Antonio Rensi Colturato Andréia Pedro Clarissa Vasconcellos de Souza Elenaide Coutinho Nunes Eliana Cristina Martins Miranda Kátia Camacho Marcos Augusto Mauad Maria Elvira Pizzigatti Correa Márcia de Matos Silva Mair Pedro de Sousa Rita de Cássia Barbosa da Silva Tavares Stephanie Joi Lee Mary Evelyn Dantas Flowers

BACKGROUND: New criteria for the diagnosis and classification of chronic graft-versus-host disease were developed in 2005 for the purpose of clinical trials with a consensus sponsored by the National Institute of Health. OBJECTIVES: The aim of this study is to present the results of a multicenter pilot study performed by the Brazil-Seattle chronic graft-versus-host disease consortium to determ...

Journal: :Blood 2002
Stephen Couban David R Simpson Michael J Barnett Christopher Bredeson Lothar Hubesch Kang Howson-Jan Tsiporah B Shore Irwin R Walker Peter Browett Hans A Messner Tony Panzarella Jeffrey H Lipton

Cytokine-mobilized peripheral blood is increasingly used instead of bone marrow as the source of cells for allogeneic transplantation. Although cells lead to faster hematologic recovery, their effects on graft-versus-host disease, relapse, and survival are less certain. Between January 1996 and February 2000, 228 patients with chronic myeloid leukemia, acute myeloid leukemia, or myelodysplasia ...

2016
Sridevi Nair Murugesan Vanathi Anita Ganger Radhika Tandon

Allogenic haematological stem cell transplantation (allo-SCT) from a human leukocyte antigen (HLA) matched related or unrelated donor is used as a curative therapy for a large number of malignant and non-malignant haematological diseases. The curative effect of allo-SCT is achieved by graft versus leukaemia effect while the downside of the graft versus patient activity is the graftversus-host-d...

2008
Gabriel H. Lipshutz Felix S. Chew

We present the case of a 54-year-old woman who had calcinosis cutis related to sclerodermatous chronic graft versus host disease. Graft versus host disease had developed following stem cell transplantation for acute myelogenous leukemia 14 years earlier, but was shown by skin biopsy to have resolved by the time of presentation. Radiographs showed extensive cutaneous calcifications in the lower ...

2009
Gabriel H. Lipshutz Felix S. Chew

We present the case of a 54-year-old woman who had calcinosis cutis related to sclerodermatous chronic graft versus host disease. Graft versus host disease had developed following stem cell transplantation for acute myelogenous leukemia 14 years earlier, but was shown by skin biopsy to have resolved by the time of presentation. Radiographs showed extensive cutaneous calcifications in the lower ...

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