Cupriavidus gilardii is a Gram-negative bacterium that has rarely been associated with human infections. We report a fatal case of sepsis caused by C. gilardii in a previously healthy 12-year-old female.

Lipopolysaccharide (LPS), purified from gram-negative bacteria, is well known to induce proinflammatory responses in monocytes and macrophages, and release of LPS from the microbial surface has been suggested to be an important initiating event in the sepsis syndrome. However, numerous studies have documented that a variety of constituents present in the outer cell membrane of gram-negative bac...

discussion: the present case demonstrates that the uropathogenic e. hermanii clone can cause destruction of the kidneys. during asymptomatic bacteriuria or cystitis, the bacteria remain in the urinary tract. even when pyelonephritis develops, inflammatory response of the host is still restricted to the urinary tract. these signs mean that uropathogenic e. hermanii may be not very virulent. intr...

background :   imipenem-resistant gram negative bacteria, resulting from metallo-beta-lactamase (mbls)-producing strains have been reported to be among the important causes of nosocomial infections and of serious therapeutic problem worldwide. because of their broad range, potent carbapenemase activity and resistance to inhibitors, these enzymes can confer resistance to almost all beta-lactams....

About 20 % of neonates develop sepsis and among them approximately 1% die due to sepsis-related causes. Bacterial pathogens are the commonest cause neonatal which is either early-onset (<72 hours age) or late-onset (>72 hours). Little known about epidemiology antimicrobial susceptibility pattern causing bacterial in Nepal. A prospective study was carried out suspected have admitted Tribhu...

Sensing of lipopolysaccharide (LPS) in the cytosol triggers caspase-11 activation and is central to host defense against Gram-negative bacterial infections and to the pathogenesis of sepsis. Most Gram-negative bacteria that activate caspase-11, however, are not cytosolic, and the mechanism by which LPS from these bacteria gains access to caspase-11 in the cytosol remains elusive. Here, we ident...

bacterial sepsis is one of the most common causes of mortality and morbidity in neonates. it has been recognized a gradual change in spectrum of organisms responsible for neonatal sepsis. in this study we have evaluated changing trend of incidence and antibiotic susceptibility in neonatal late - onset sepsis (los) in 2-periods. this study is based on results of blood culture in neonatal late-on...

BACKGROUND Identification of new therapeutic targets remains an imperative goal to improve the morbidity and mortality associated with severe sepsis and septic shock. Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine and counterregulator of glucocorticoids, has recently emerged as a critical mediator of innate immunity and experimental sepsis, and it is an attractive new ...

Introduction Early diagnosis of sepsis is the key for improving the survival, therefore biomarkers have an important place in this process because they can indicate the presence or absence of sepsis [1]. Procalcitonin aids in diagnosis and risk stratification of bacterial sepsis [2].Using pro-BNP as inflammatory marker in diagnosing severe sepsis and septic shock is based on cytokines productio...

Sepsis is a principal cause of death in critical care units worldwide and consumes considerable healthcare resources. The aim of our study was to determine whether the early cytokine profile can discriminate between Gram-positive and Gram-negative bacteraemia (GPB and GNB, respectively) and to assess the prognostic value regarding outcome in critically ill patients with severe abdominal sepsis....